FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074825188> ?p ?o ?g. }

• W2074825188 endingPage "e1531" @default.
• W2074825188 startingPage "e1531" @default.
• W2074825188 abstract "Senescence is characterized by permanent cell-cycle arrest despite continued viability and metabolic activity, in conjunction with the secretion of a complex mixture of extracellular proteins and soluble factors known as the senescence-associated secretory phenotype (SASP). Cellular senescence has been shown to prevent the proliferation of potentially tumorigenic cells, and is thus generally considered a tumor suppressive process. However, some SASP components may act as pro-tumorigenic mediators on premalignant cells in the microenvironment. A limited number of studies indicated that protein kinase C (PKC) has a role in senescence, with different isoforms having opposing effects. It is therefore important to elucidate the functional role of specific PKCs in senescence. Here we show that PKCη, an epithelial specific and anti-apoptotic kinase, promotes senescence induced by oxidative stress and DNA damage. We further demonstrate that PKCη promotes senescence through its ability to upregulate the expression of the cell cycle inhibitors p21Cip1 and p27Kip1 and enhance transcription and secretion of interleukin-6 (IL-6). Moreover, we demonstrate that PKCη creates a positive loop for reinforcing senescence by increasing the transcription of both IL-6 and IL-6 receptor, whereas the expression of IL-8 is specifically suppressed by PKCη. Thus, the presence/absence of PKCη modulates major components of SASP. Furthermore, we show that the human polymorphic variant of PKCη, 374I, that exhibits higher kinase activity in comparison to WT-374V, is also more effective in IL-6 secretion, p21Cip1 expression and the promotion of senescence, further supporting a role for PKCη in senescence. As there is now considerable interest in senescence activation/elimination to control tumor progression, it is first crucial to reveal the molecular regulators of senescence. This will improve our ability to develop new strategies to harness senescence as a potential cancer therapy in the future." @default.
• W2074825188 created "2016-06-24" @default.
• W2074825188 creator A5005173745 @default.
• W2074825188 creator A5006158729 @default.
• W2074825188 creator A5031898607 @default.
• W2074825188 creator A5048678365 @default.
• W2074825188 creator A5079119964 @default.
• W2074825188 creator A5084716736 @default.
• W2074825188 date "2014-11-20" @default.
• W2074825188 modified "2023-10-09" @default.
• W2074825188 title "PKCη promotes senescence induced by oxidative stress and chemotherapy" @default.
• W2074825188 cites W1501211852 @default.
• W2074825188 cites W1930421942 @default.
• W2074825188 cites W1965867424 @default.
• W2074825188 cites W1966042998 @default.
• W2074825188 cites W1973300568 @default.
• W2074825188 cites W1974297564 @default.
• W2074825188 cites W1978265027 @default.
• W2074825188 cites W1995205742 @default.
• W2074825188 cites W1997372802 @default.
• W2074825188 cites W1999015877 @default.
• W2074825188 cites W2000906131 @default.
• W2074825188 cites W2005248738 @default.
• W2074825188 cites W2010417927 @default.
• W2074825188 cites W2018321060 @default.
• W2074825188 cites W2033175728 @default.
• W2074825188 cites W2034332058 @default.
• W2074825188 cites W2037493777 @default.
• W2074825188 cites W2042418128 @default.
• W2074825188 cites W2044341880 @default.
• W2074825188 cites W2047175163 @default.
• W2074825188 cites W2053641528 @default.
• W2074825188 cites W2055552531 @default.
• W2074825188 cites W2061619522 @default.
• W2074825188 cites W2061765285 @default.
• W2074825188 cites W2062107951 @default.
• W2074825188 cites W2062933650 @default.
• W2074825188 cites W2063651430 @default.
• W2074825188 cites W2071779521 @default.
• W2074825188 cites W2074274602 @default.
• W2074825188 cites W2077450385 @default.
• W2074825188 cites W2078790300 @default.
• W2074825188 cites W2085354593 @default.
• W2074825188 cites W2085932251 @default.
• W2074825188 cites W2087100775 @default.
• W2074825188 cites W2090949169 @default.
• W2074825188 cites W2102008562 @default.
• W2074825188 cites W2103719933 @default.
• W2074825188 cites W2104908670 @default.
• W2074825188 cites W2108273756 @default.
• W2074825188 cites W2110934787 @default.
• W2074825188 cites W2116054786 @default.
• W2074825188 cites W2116437342 @default.
• W2074825188 cites W2123173724 @default.
• W2074825188 cites W2130198345 @default.
• W2074825188 cites W2131078803 @default.
• W2074825188 cites W2132224453 @default.
• W2074825188 cites W2133933675 @default.
• W2074825188 cites W2136380412 @default.
• W2074825188 cites W2144626763 @default.
• W2074825188 cites W2146113536 @default.
• W2074825188 cites W2148760047 @default.
• W2074825188 cites W2150740687 @default.
• W2074825188 cites W2153617345 @default.
• W2074825188 cites W2153819797 @default.
• W2074825188 cites W2167052297 @default.
• W2074825188 cites W2167244325 @default.
• W2074825188 cites W2196534938 @default.
• W2074825188 cites W2220374831 @default.
• W2074825188 cites W2272429631 @default.
• W2074825188 cites W2316417922 @default.
• W2074825188 cites W2322555451 @default.
• W2074825188 cites W2330484539 @default.
• W2074825188 cites W2412105346 @default.
• W2074825188 cites W2414288997 @default.
• W2074825188 cites W2463243175 @default.
• W2074825188 doi "https://doi.org/10.1038/cddis.2014.481" @default.
• W2074825188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4260739" @default.
• W2074825188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25412309" @default.
• W2074825188 hasPublicationYear "2014" @default.
• W2074825188 type Work @default.
• W2074825188 sameAs 2074825188 @default.
• W2074825188 citedByCount "27" @default.
• W2074825188 countsByYear W20748251882015 @default.
• W2074825188 countsByYear W20748251882016 @default.
• W2074825188 countsByYear W20748251882017 @default.
• W2074825188 countsByYear W20748251882018 @default.
• W2074825188 countsByYear W20748251882019 @default.
• W2074825188 countsByYear W20748251882020 @default.
• W2074825188 countsByYear W20748251882021 @default.
• W2074825188 countsByYear W20748251882022 @default.
• W2074825188 countsByYear W20748251882023 @default.
• W2074825188 crossrefType "journal-article" @default.
• W2074825188 hasAuthorship W2074825188A5005173745 @default.
• W2074825188 hasAuthorship W2074825188A5006158729 @default.
• W2074825188 hasAuthorship W2074825188A5031898607 @default.
• W2074825188 hasAuthorship W2074825188A5048678365 @default.
• W2074825188 hasAuthorship W2074825188A5079119964 @default.

• next