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• W2074828464 abstract "The L-azetidine-2-carboxylic acid (Aze) residue can be incorporated into proteins in the place of L-proline, of which it is the lower homologue. This substitution alters the properties of proteins, especially of collagen. Conformational constraints in N-acetyl-Aze-N'-methylamide and in several dipeptides containing Aze have been analyzed by means of energy computations. They have been compared with peptides containing Pro. The overall conformational preferences of Aze and Pro are similar, but several significant differences occur between them. In general, peptides containing Aze are somewhat more flexible than corresponding peptides containing Pro, because of a decrease in constraints caused by repulsive nonconvalent interactions of the atoms of the ring with neighboring residues. This results in an entropic effect that lessens the stability of ordered polypeptide conformations with respect to the disordered statistical coil. The collagen-like near-extended conformation is energetically less favorable for Aze than for Pro in the single residue and in dipeptides. This effect also contributes to a destabilization of the collagen triple helix. The influence of Aze on the conformation of polypeptides is discussed in the accompanying papers." @default.
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• W2074828464 date "1990-01-01" @default.
• W2074828464 modified "2023-10-16" @default.
• W2074828464 title "The effect of the <scp>L</scp>‐azetidine‐2‐carboxylic acid residue on protein conformation. I. Conformations of the residue and of dipeptides" @default.
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• W2074828464 doi "https://doi.org/10.1002/bip.360300909" @default.
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