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- W2074845884 abstract "L(+)-threo-chloramphenicol induces reversion of His−Salmonella typhimurium strains TA100 and TA1535 in the conventional Ames' assay without microsomal activation. Any mutagenicity of D(−)-threo-chloramphenicol was masked by toxicity. Similarly, a sensitive fluctuation test showed mutagenesis with L(+)-threo-chloramphenicol at concentrations of 0.5 μM and above but the D(−) isomer proved to be toxic even at these low levels. The L(+) isomer caused single strand breaks in the DNA of Escherichia coliBr and Salmonella typhimurium strains TA1535, TA100 and TA1976. The D(−) isomer caused breaks in Escherichia coliBr and Salmonella typhimurium TA1976 although it was less effective and it did not produce DNA breaks in TA1535 or TA100." @default.
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- W2074845884 date "1977-09-01" @default.
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- W2074845884 title "Chloramphenicol damages bacterial DNA" @default.
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- W2074845884 doi "https://doi.org/10.1016/0006-291x(77)91233-5" @default.
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