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- W2074857093 abstract "Abstract [4- 14 C]-Oestradiol was incubated with liver slices of two male subjects. Under the protection of ascorbic acid the metabolites formed were separated into the free steroid, sulphate, glucuronide and thioether fractions. Using different Chromatographic and hydrolytic procedures the metabolites were isolated and identified by various microchemical reactions. Apart from oestradiol (31%) and oestrone (31%) the 2-substituted oestrogens 2-hydroxy-oestradiol (5.3%), 2-hydroxyoestrone (2.6%), 2-hydroxyoestrone 2-methyl ether (2.2%) and 2-hydroxyoestradiol 2-methyl ether (2.2%) were found to be the main metabolites (13%). They were present as free steroids (7.3%), sulphates (4.8%), glucuronides (0.3%) and thioethers (0.1%). Conjugation of the catechol oestrogens with either sulphuric acid or with glucuronic acid was only found at the 2-hydroxy group. The amount of ring B and ring D hydroxylated compounds did not exceed 3.8 and 0.5%, respectively. This means that the metabolism of oestradiol mainly proceeds via 2-hydroxylation and further metabolism of the 2-hydroxylated oestrogens. The intermediary metabolism of catechol oestrogens formed after incubation of oestradiol was essentially the same as that after direct incubation of [4- 14 C]-2-hydroxyoestradiol. When [4- 14 C]-oestradiol was administered orally to the same two male subjects 4 weeks after the liver excision the following excretion pattern of metabolites was found in the 72 h urine: 2-substituted oestrogens were the main catabolic products (11%), followed by oestrone and oestradiol (8.0%) and 16α-hydroxylated compounds (6.4%). All metabolites were mainly present as glucuronides." @default.
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- W2074857093 date "1976-02-01" @default.
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- W2074857093 title "Comparative studies on the metabolism of oestradiol-17β and 2-hydroxy-oestradiol-17β in man in vitro and in vivo" @default.
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- W2074857093 doi "https://doi.org/10.1016/0022-4731(76)90150-3" @default.
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