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- W2074865449 abstract "Purpose of review Variants in the hepatocyte nuclear factor 4α (HNF4A) gene play a role in the development of diabetes mellitus. Although genetic variation in and around HNF4A regulatory regions has received considerable attention, the significance of these variants in the common type 2 diabetes varies in the literature. This review will provide a general overview of recent genetic studies involving the evaluation of HNF4A as a contributor to the risk and pathophysiology of diabetes mellitus and related risk factors. Recent findings These studies report newly identified variants, evaluate previously reported polymorphisms that were associated with type 2 diabetes in several distinct populations with maturity-onset diabetes of the young, type 2 diabetes, gestational diabetes, and diabetes related risk factors, and propose a role for HNF4A in insulin secretion via the potassium ATP channel. Summary HNF4A variants identified so far appear to modestly contribute to predisposition for type 2 diabetes. Continued identification and especially functional characterization of variants, however, will be critical in future studies to enhance our understanding of the metabolic impact of this gene." @default.
- W2074865449 created "2016-06-24" @default.
- W2074865449 creator A5023938814 @default.
- W2074865449 creator A5083501945 @default.
- W2074865449 date "2007-07-01" @default.
- W2074865449 modified "2023-09-24" @default.
- W2074865449 title "HNF4A genetic variants: role in diabetes" @default.
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- W2074865449 cites W1989465060 @default.
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- W2074865449 doi "https://doi.org/10.1097/mco.0b013e3281e3888d" @default.
- W2074865449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17563455" @default.
- W2074865449 hasPublicationYear "2007" @default.
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