Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074872567> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2074872567 endingPage "e121" @default.
- W2074872567 startingPage "e120" @default.
- W2074872567 abstract "Objective: Polyphenols in red wine are believed to improve endothelial function. We investigated whether daily consumption of red wine improves in vivo vascular function. After ingestion, red wine components are present for some time in the circulation. Therefore, we also studied whether incubation of porcine coronary arteries (PCAs) with red wine extract (RWE) improves vascular function in vitro. Methods: Eighteen young healthy women drank red wine daily for three weeks. Vascular function was evaluated as forearm blood flow (FBF). For the in vitro study, PCAs were suspended in organ baths in the absence or presence of the NOS inhibitor L-NAME and/or the soluble guanylyl cyclase (sGC) inhibitor ODQ. In a number of vessels, the endothelium was removed. Concentration-response curves to RWE were constructed following preconstriction with U46619. The effect of RWE incubation was studied by quantifying bradykinin- and S-nitroso-N-penicillamine (SNAP)- induced vasorelaxation following acute (0.5 hour and 2 hours) or chronic (16 hours) pre-incubation with RWE. Results: Acetylcholine-induced, endothelium-dependent and sodium nitroprusside-induced, endothelium-independent FBF increases were enhanced after three weeks of red wine consumption, but not acutely after one unit of red wine (corresponding with 10 g of alcohol). In vitro, RWE fully relaxed U46619-preconstricted PCAs. This effect was endothelium-dependent and strongly reduced by L-NAME and ODQ. Acute pre-incubation with RWE blocked bradykinin-induced relaxation, and this effect tended to disappear upon chronic pre-incubation. Similarly, acute, but not chronic, RWE pre-incubation diminished the SNAP-induced response. Conclusions: In vitro, RWE causes endothelium-dependent, NO- and sGC-mediated relaxations of coronary arteries. Pre-incubation with RWE reduces the bradykinin- and SNAP-induced relaxation, possibly via sGC inactivation induced by the high levels of NO generated by RWE. This effect disappears upon prolonged pre-incubation. These data are in line with our in vivo results, where the lack of an acute effect of red wine may be attributed to sGC inactivation, whereas the improved effect after prolonged wine exposure may reflect sGC upregulation and/or structural vascular alterations." @default.
- W2074872567 created "2016-06-24" @default.
- W2074872567 creator A5021155722 @default.
- W2074872567 creator A5049615729 @default.
- W2074872567 creator A5065678814 @default.
- W2074872567 creator A5084991484 @default.
- W2074872567 date "2010-06-01" @default.
- W2074872567 modified "2023-10-18" @default.
- W2074872567 title "DAILY RED WINE CONSUMPTION IMPROVES VASCULAR FUNCTION IN YOUNG HEALTHY WOMEN, PROPABLY BY AN ENDOTHELIUM-DEPENDENT NITRIC OXIDE-SOLUBLE GUANYLYL CYCLASE - MEDIATED PATHWAY: PP.6.236" @default.
- W2074872567 doi "https://doi.org/10.1097/01.hjh.0000378560.54656.1b" @default.
- W2074872567 hasPublicationYear "2010" @default.
- W2074872567 type Work @default.
- W2074872567 sameAs 2074872567 @default.
- W2074872567 citedByCount "0" @default.
- W2074872567 crossrefType "journal-article" @default.
- W2074872567 hasAuthorship W2074872567A5021155722 @default.
- W2074872567 hasAuthorship W2074872567A5049615729 @default.
- W2074872567 hasAuthorship W2074872567A5065678814 @default.
- W2074872567 hasAuthorship W2074872567A5084991484 @default.
- W2074872567 hasBestOaLocation W20748725671 @default.
- W2074872567 hasConcept C126322002 @default.
- W2074872567 hasConcept C134018914 @default.
- W2074872567 hasConcept C170493617 @default.
- W2074872567 hasConcept C173803235 @default.
- W2074872567 hasConcept C185592680 @default.
- W2074872567 hasConcept C25642318 @default.
- W2074872567 hasConcept C2776992346 @default.
- W2074872567 hasConcept C2778827303 @default.
- W2074872567 hasConcept C2779591629 @default.
- W2074872567 hasConcept C2779610285 @default.
- W2074872567 hasConcept C31903555 @default.
- W2074872567 hasConcept C519581460 @default.
- W2074872567 hasConcept C55493867 @default.
- W2074872567 hasConcept C55952523 @default.
- W2074872567 hasConcept C71924100 @default.
- W2074872567 hasConcept C98274493 @default.
- W2074872567 hasConceptScore W2074872567C126322002 @default.
- W2074872567 hasConceptScore W2074872567C134018914 @default.
- W2074872567 hasConceptScore W2074872567C170493617 @default.
- W2074872567 hasConceptScore W2074872567C173803235 @default.
- W2074872567 hasConceptScore W2074872567C185592680 @default.
- W2074872567 hasConceptScore W2074872567C25642318 @default.
- W2074872567 hasConceptScore W2074872567C2776992346 @default.
- W2074872567 hasConceptScore W2074872567C2778827303 @default.
- W2074872567 hasConceptScore W2074872567C2779591629 @default.
- W2074872567 hasConceptScore W2074872567C2779610285 @default.
- W2074872567 hasConceptScore W2074872567C31903555 @default.
- W2074872567 hasConceptScore W2074872567C519581460 @default.
- W2074872567 hasConceptScore W2074872567C55493867 @default.
- W2074872567 hasConceptScore W2074872567C55952523 @default.
- W2074872567 hasConceptScore W2074872567C71924100 @default.
- W2074872567 hasConceptScore W2074872567C98274493 @default.
- W2074872567 hasLocation W20748725671 @default.
- W2074872567 hasLocation W20748725672 @default.
- W2074872567 hasOpenAccess W2074872567 @default.
- W2074872567 hasPrimaryLocation W20748725671 @default.
- W2074872567 hasRelatedWork W1983925881 @default.
- W2074872567 hasRelatedWork W1991289091 @default.
- W2074872567 hasRelatedWork W2022024682 @default.
- W2074872567 hasRelatedWork W2051915947 @default.
- W2074872567 hasRelatedWork W2090270552 @default.
- W2074872567 hasRelatedWork W2161966493 @default.
- W2074872567 hasRelatedWork W2294614927 @default.
- W2074872567 hasRelatedWork W2405116268 @default.
- W2074872567 hasRelatedWork W3145273514 @default.
- W2074872567 hasRelatedWork W4251646540 @default.
- W2074872567 hasVolume "28" @default.
- W2074872567 isParatext "false" @default.
- W2074872567 isRetracted "false" @default.
- W2074872567 magId "2074872567" @default.
- W2074872567 workType "article" @default.