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- W2074885911 abstract "Abstract Autophagy is an evolutionarily conserved lysosomal mechanism implicated in a wide variety of pathological processes, such as cancer. Autophagy can be regulated by a limited number of autophagy‐related genes (Atgs) such as oncogenic Bcl‐2 / Bcl‐X L , mTORC1 , Akt and PI3KCI , and tumour suppressive proteins PI3KCIII, Beclin‐1, Bif‐1, p53, DAPKs, PTEN and UVRAG , which play their crucial roles in regulating autophagy‐related cancer. As autophagy has a dual role in cancer cells, with tumour‐promoting and tumour‐suppressing properties, it has become an attractive target for a series of emerging small molecule drugs. In this review, we reveal new discoveries of related small molecules or chemical compounds that can regulate autophagic pathways and lead to pro‐death or pro‐survival autophagy, in different types of cancer. We discuss the knots between autophagic targets and candidate drugs, in the hope of shedding new light on exploiting new anti‐tumour small molecule drugs for future cancer therapy." @default.
- W2074885911 created "2016-06-24" @default.
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- W2074885911 creator A5085352453 @default.
- W2074885911 date "2015-02-04" @default.
- W2074885911 modified "2023-10-18" @default.
- W2074885911 title "Untangling knots between autophagic targets and candidate drugs, in cancer therapy" @default.
- W2074885911 cites W1523693806 @default.
- W2074885911 cites W1544583478 @default.
- W2074885911 cites W1555054913 @default.
- W2074885911 cites W1563936556 @default.
- W2074885911 cites W1589349878 @default.
- W2074885911 cites W1640748843 @default.
- W2074885911 cites W1835985642 @default.
- W2074885911 cites W1880079952 @default.
- W2074885911 cites W1930141236 @default.
- W2074885911 cites W1964272901 @default.
- W2074885911 cites W1965189712 @default.
- W2074885911 cites W1968444524 @default.
- W2074885911 cites W1970958073 @default.
- W2074885911 cites W1971854397 @default.
- W2074885911 cites W1975403576 @default.
- W2074885911 cites W1977539225 @default.
- W2074885911 cites W1979319226 @default.
- W2074885911 cites W1980087941 @default.
- W2074885911 cites W1980328444 @default.
- W2074885911 cites W1980328627 @default.
- W2074885911 cites W1980422085 @default.
- W2074885911 cites W1982973163 @default.
- W2074885911 cites W1983660153 @default.
- W2074885911 cites W1983831622 @default.
- W2074885911 cites W1983889487 @default.
- W2074885911 cites W1985731139 @default.
- W2074885911 cites W1986353709 @default.
- W2074885911 cites W1990238517 @default.
- W2074885911 cites W1991398927 @default.
- W2074885911 cites W1991937010 @default.
- W2074885911 cites W1992034322 @default.
- W2074885911 cites W1995229256 @default.
- W2074885911 cites W1995391763 @default.
- W2074885911 cites W1996068251 @default.
- W2074885911 cites W1996323392 @default.
- W2074885911 cites W1996936702 @default.
- W2074885911 cites W1998943082 @default.
- W2074885911 cites W1999306559 @default.
- W2074885911 cites W1999537070 @default.
- W2074885911 cites W2001036106 @default.
- W2074885911 cites W2001236893 @default.
- W2074885911 cites W2001540049 @default.
- W2074885911 cites W2002424586 @default.
- W2074885911 cites W2002636911 @default.
- W2074885911 cites W2009685214 @default.
- W2074885911 cites W2010623582 @default.
- W2074885911 cites W2011282245 @default.
- W2074885911 cites W2011608072 @default.
- W2074885911 cites W2011884359 @default.
- W2074885911 cites W2013523794 @default.
- W2074885911 cites W2014147259 @default.
- W2074885911 cites W2015442288 @default.
- W2074885911 cites W2017453518 @default.
- W2074885911 cites W2018535512 @default.
- W2074885911 cites W2023280816 @default.
- W2074885911 cites W2024733678 @default.
- W2074885911 cites W2024945535 @default.
- W2074885911 cites W2025266915 @default.
- W2074885911 cites W2025299523 @default.
- W2074885911 cites W2026198376 @default.
- W2074885911 cites W2027214449 @default.
- W2074885911 cites W2027216014 @default.
- W2074885911 cites W2027385366 @default.
- W2074885911 cites W2028744406 @default.
- W2074885911 cites W2032629397 @default.
- W2074885911 cites W2033554712 @default.
- W2074885911 cites W2034744993 @default.
- W2074885911 cites W2034973961 @default.
- W2074885911 cites W2035582117 @default.
- W2074885911 cites W2037711165 @default.
- W2074885911 cites W2038387569 @default.
- W2074885911 cites W2038824854 @default.
- W2074885911 cites W2040792964 @default.
- W2074885911 cites W2041221324 @default.
- W2074885911 cites W2042350981 @default.
- W2074885911 cites W2042377836 @default.
- W2074885911 cites W2043324280 @default.
- W2074885911 cites W2044621729 @default.
- W2074885911 cites W2045146500 @default.
- W2074885911 cites W2045271263 @default.
- W2074885911 cites W2048030072 @default.
- W2074885911 cites W2048636810 @default.
- W2074885911 cites W2050634374 @default.
- W2074885911 cites W2051352227 @default.