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• W2074889849 abstract "The effects of histone 2A and some polycations on microsomal carbamylphosphate:d-glucose phosphotransferase and glucose-6-phosphate phosphohydrolase activities (d-glucose-6-phosphate phoshohydrolase, EC 3.1.3.9), have been investigated. 1. Histone 2A and polycations activate the enzymic activities. At a constant cation concentration, this activation increases with the number of cationic groups per molecule. 2. Activation by histone 2A is related to its fixation on microsomal membranes. This fixation varies with quantities of histones and pH. 3. The nature of the interactions between histones and microsomal membranes is shown to be electrostatic, probably between the cationic groups of histones and the anionic group of membranous lipids. 4. Kinetic analysis reveal that histone 2A increases the maximal reaction velocity but does not affect the apparent Michaelis constant values for the substrates. 5. The role played by the cationic groups of histone 2A on the microsomal glucose 6-phosphatase, is discussed. L'action de petites protéines basiques, plus particulièrement d'histones 2A de thymus de veau, et d'autres polycations sur les activités glucose-6-phosphate phosphohydrolase (d-glucose-6-phosphate phosphohydrolase, EC 3.1.3.9) et EC 3.1.3.9) et carbamyl-phosphate:d-glucose phosphotransférase des microsomes d'hépatocytes de singe adulte, a été étudiée. 1. Les polycations, dont les histones 2A, exercent un effect activateur sur les deux activités enzymatiques étudiées. Cet effet augmente avec le nombre de groupements cationiques par molécule pour une concentration en cations constante. 2. L'activation par les histones 2A est en corrélation avec sa fixation sur les membranes microsomiques. Cette fixation varie en fonction du pH et de la quantité d'histones présentes. 3. Les interactions histones-membranes microsomiques seraient de nature électrostatique vraisemblablement entre les groupements cationiques des histones et les fonctions anioniques des phospholipides membranaires. 4. L'activation porte uniquement sur la vitesse de catalyse enzymatique sans affecter l'affinité de l'enzyme vis-à-vis de son ou ses substrats. 5. Une interprétation de l'action des groupements cationiques des histones 2A et autres polycations vis-à-vis des deux activités de la glucose-6-phosphatase microsomique est discutée." @default.
• W2074889849 created "2016-06-24" @default.
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• W2074889849 date "1980-08-01" @default.
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• W2074889849 title "Effet de petites proteines basiques sur les activites phosphohydrolase et phosphotransferase de la glucose-6-phosphatase microsomique des hepatocytes de singe" @default.
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• W2074889849 doi "https://doi.org/10.1016/0005-2744(80)90229-6" @default.
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