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- W2074890991 abstract "MoxXT module of Bacillus anthracis encodes MoxX, a labile protein and MoxT, a ribonuclease. However, mechanism of cleavage of RNA by MoxT has not been explored till date. In the present study, we have demonstrated that MoxT is a sequence specific ribonuclease which recognizes UACAU sequence in ss RNA and cleaves between U and A. Moreover, cleavage of RNA requires 2′ OH group of first residue, i.e. U of UACAU RNA sequence. An interesting finding which makes it distinct from the other MazF family toxins was also observed, i.e. its ability to cleave RNA in DNA–RNA hybrid." @default.
- W2074890991 created "2016-06-24" @default.
- W2074890991 creator A5015254541 @default.
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- W2074890991 date "2014-07-01" @default.
- W2074890991 modified "2023-09-25" @default.
- W2074890991 title "MoxT toxin of Bacillus anthracis exhibits sequence specific ribonuclease activity" @default.
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- W2074890991 doi "https://doi.org/10.1016/j.bbrc.2014.06.092" @default.
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