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• W2074892275 abstract "<h3>Objective:</h3> To identify early prognostic factors of relapse and disability in children presenting with an acute idiopathic transverse myelitis (TM). <h3>Methods:</h3> Ninety-five children with acute idiopathic TM from 2 national European cohorts (France and United Kingdom) of CNS demyelinating diseases in children were identified and studied for early factors that predict relapse and disability using logistic regression models. <h3>Results:</h3> Sixteen (17%) relapsed, with a diagnosis of multiple sclerosis in 13 (14%) and neuromyelitis optica in 3 (3%). Logistic regression revealed 2 main criteria as risk factors for relapse: female sex (odds ratio [OR] 3.21, 95% confidence interval [CI] 0.88–11.78) and presence of associated brain lesions (OR 14.0, 95% CI 2.8–69.3). Twenty-eight (30%) children had a poor outcome defined by a Kurtzke Expanded Disability Status Scale score ≥4 or an American Spinal Injury Association impairment (ASIA) scale <D at last follow-up. Five factors were associated with poor outcome: female sex (OR 5.8, 95% CI 0.99–32.7), severe ASIA scale at onset (OR 33.5, 95% CI 1.8–618), gadolinium enhancement on spinal MRI (OR 24.1, 95% CI 3.78–153.88), absence of pleocytosis (OR 4.6, 95% CI 0.87–26.0), and absence of cervical or cervico-thoracic lesion on spinal MRI (OR 3.9, 95% CI 0.78–19.6). <h3>Conclusions</h3> Early predictors of relapse and disability identified in this large childhood study of acute idiopathic TM have important utility for clinical management. Larger prospective collaborative studies are required to validate these findings, which may improve the design of clinical trials." @default.
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• W2074892275 date "2014-12-24" @default.
• W2074892275 modified "2023-09-30" @default.
• W2074892275 title "Acute idiopathic transverse myelitis in children: Early predictors of relapse and disability" @default.
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• W2074892275 doi "https://doi.org/10.1212/wnl.0000000000001179" @default.
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