Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074893312> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2074893312 endingPage "107" @default.
- W2074893312 startingPage "104" @default.
- W2074893312 abstract "Background The expression of several genes is modulated during neuroblastoma differentiation. The retinoblastoma family proteins, pRb, p107 and pRb2/p130, act in the repression of proliferation genes, interacting mainly with the E2F transcription factors. Procedure and Results In this study, we found that, in neuroblastoma cell lines, pRb and p107 proteins decreased, undergoing progressive dephosphorylation, whereas pRb2/p130 increased at late stages of differentiation. B-myb expression was down-regulated in association with the up-regulation of pRb2/p130, the major partner of E2F on the E2F site of the B-myb promoter in differentiated cells. Transfection of each of the retinoblastoma family genes in neuroblastoma cells was able to induce neural differentiation, to inhibit 3H-thymidine incorporation, and to down-regulate B-myb promoter activity. Conclusions In conclusion, our data suggest a major contribution of retinoblastoma proteins, and especially of pRb2/p130, in B-myb promoter regulation and demonstrate the induction of neural differentiation by p107 and pRb2/p130, suggesting a role of these proteins in triggering differentiation-specific genes. Med. Pediatr. Oncol. 36:104–107, 2001. © 2001 Wiley-Liss, Inc." @default.
- W2074893312 created "2016-06-24" @default.
- W2074893312 creator A5025801646 @default.
- W2074893312 creator A5031306014 @default.
- W2074893312 creator A5044974615 @default.
- W2074893312 creator A5056224853 @default.
- W2074893312 creator A5066958540 @default.
- W2074893312 creator A5075084581 @default.
- W2074893312 date "2001-01-01" @default.
- W2074893312 modified "2023-10-17" @default.
- W2074893312 title "Retinoblastoma family proteins induce differentiation and regulate B-myb expression in neuroblastoma cells" @default.
- W2074893312 cites W1964630435 @default.
- W2074893312 cites W1980096047 @default.
- W2074893312 cites W1980131968 @default.
- W2074893312 cites W1983116950 @default.
- W2074893312 cites W2025699039 @default.
- W2074893312 cites W2026106245 @default.
- W2074893312 cites W2029824360 @default.
- W2074893312 cites W2033473752 @default.
- W2074893312 cites W2038467457 @default.
- W2074893312 cites W2043268943 @default.
- W2074893312 cites W2064428081 @default.
- W2074893312 cites W2073960683 @default.
- W2074893312 cites W2075280050 @default.
- W2074893312 cites W2085312521 @default.
- W2074893312 cites W2128111424 @default.
- W2074893312 cites W2321856961 @default.
- W2074893312 cites W2329891521 @default.
- W2074893312 cites W327522344 @default.
- W2074893312 cites W4312036571 @default.
- W2074893312 doi "https://doi.org/10.1002/1096-911x(20010101)36:1<104::aid-mpo1024>3.0.co;2-9" @default.
- W2074893312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11464857" @default.
- W2074893312 hasPublicationYear "2001" @default.
- W2074893312 type Work @default.
- W2074893312 sameAs 2074893312 @default.
- W2074893312 citedByCount "5" @default.
- W2074893312 countsByYear W20748933122021 @default.
- W2074893312 crossrefType "journal-article" @default.
- W2074893312 hasAuthorship W2074893312A5025801646 @default.
- W2074893312 hasAuthorship W2074893312A5031306014 @default.
- W2074893312 hasAuthorship W2074893312A5044974615 @default.
- W2074893312 hasAuthorship W2074893312A5056224853 @default.
- W2074893312 hasAuthorship W2074893312A5066958540 @default.
- W2074893312 hasAuthorship W2074893312A5075084581 @default.
- W2074893312 hasConcept C104317684 @default.
- W2074893312 hasConcept C148738053 @default.
- W2074893312 hasConcept C150194340 @default.
- W2074893312 hasConcept C153911025 @default.
- W2074893312 hasConcept C183022183 @default.
- W2074893312 hasConcept C186310378 @default.
- W2074893312 hasConcept C2776062698 @default.
- W2074893312 hasConcept C2776577112 @default.
- W2074893312 hasConcept C2776715637 @default.
- W2074893312 hasConcept C29537977 @default.
- W2074893312 hasConcept C502942594 @default.
- W2074893312 hasConcept C54355233 @default.
- W2074893312 hasConcept C62794011 @default.
- W2074893312 hasConcept C81885089 @default.
- W2074893312 hasConcept C83258922 @default.
- W2074893312 hasConcept C86339819 @default.
- W2074893312 hasConcept C86803240 @default.
- W2074893312 hasConceptScore W2074893312C104317684 @default.
- W2074893312 hasConceptScore W2074893312C148738053 @default.
- W2074893312 hasConceptScore W2074893312C150194340 @default.
- W2074893312 hasConceptScore W2074893312C153911025 @default.
- W2074893312 hasConceptScore W2074893312C183022183 @default.
- W2074893312 hasConceptScore W2074893312C186310378 @default.
- W2074893312 hasConceptScore W2074893312C2776062698 @default.
- W2074893312 hasConceptScore W2074893312C2776577112 @default.
- W2074893312 hasConceptScore W2074893312C2776715637 @default.
- W2074893312 hasConceptScore W2074893312C29537977 @default.
- W2074893312 hasConceptScore W2074893312C502942594 @default.
- W2074893312 hasConceptScore W2074893312C54355233 @default.
- W2074893312 hasConceptScore W2074893312C62794011 @default.
- W2074893312 hasConceptScore W2074893312C81885089 @default.
- W2074893312 hasConceptScore W2074893312C83258922 @default.
- W2074893312 hasConceptScore W2074893312C86339819 @default.
- W2074893312 hasConceptScore W2074893312C86803240 @default.
- W2074893312 hasIssue "1" @default.
- W2074893312 hasLocation W20748933121 @default.
- W2074893312 hasLocation W20748933122 @default.
- W2074893312 hasOpenAccess W2074893312 @default.
- W2074893312 hasPrimaryLocation W20748933121 @default.
- W2074893312 hasRelatedWork W1965185514 @default.
- W2074893312 hasRelatedWork W1980096047 @default.
- W2074893312 hasRelatedWork W2050758855 @default.
- W2074893312 hasRelatedWork W2071427066 @default.
- W2074893312 hasRelatedWork W2073792103 @default.
- W2074893312 hasRelatedWork W2074893312 @default.
- W2074893312 hasRelatedWork W2097375063 @default.
- W2074893312 hasRelatedWork W2195659777 @default.
- W2074893312 hasRelatedWork W2285366289 @default.
- W2074893312 hasRelatedWork W4239712946 @default.
- W2074893312 hasVolume "36" @default.
- W2074893312 isParatext "false" @default.
- W2074893312 isRetracted "false" @default.
- W2074893312 magId "2074893312" @default.
- W2074893312 workType "article" @default.