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• W2074900897 startingPage "1827" @default.
• W2074900897 abstract "Upon detection of direct and indirect signs of infection, dendritic cells (DC) undergo functional changes that modify their ability to elicit immune responses. Type I interferon (IFN-α/β), which includes a large family of closely related infection-inducible cytokines, represents one indirect signal that can act as a DC stimulus. We have investigated the ability of IFN-α/β subtypes to affect DC function and to influence DC responses to Toll-like receptor (TLR) agonists (i.e., direct infection-associated signals). Subtle differences were observed among 15 subtypes of IFN-α/β in the ability to stimulate expression of maturation markers and chemokines by human monocyte-derived DC, with IFN-ω being the most unique in its effects. Pre-treatment with IFN-α/β did not alter the ability of DC to mature in response to subsequent contact with TLR agonists, but did modulate their secretion of chemokines. Conversely, IFN-α/β was shown to act synergistically with TLR4 but not TLR3 agonists for the induction of maturation and chemokine production when DC were exposed to IFN-α/β and TLR ligands simultaneously. Taken together, these results indicate a complex role for IFN-α/β in regulating DC function during the course an infection, which varies according to IFN-α/β subtype and the timing of exposure to other stimuli." @default.
• W2074900897 created "2016-06-24" @default.
• W2074900897 creator A5010872908 @default.
• W2074900897 creator A5029672643 @default.
• W2074900897 date "2006-07-01" @default.
• W2074900897 modified "2023-10-18" @default.
• W2074900897 title "Modification of TLR-induced activation of human dendritic cells by type I IFN: synergistic interaction with TLR4 but not TLR3 agonists" @default.
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• W2074900897 doi "https://doi.org/10.1002/eji.200635854" @default.
• W2074900897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16783851" @default.
• W2074900897 hasPublicationYear "2006" @default.
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