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• W2074903169 abstract "In Brief Background: Liver-first reversed management (RM) for the treatment of patients with simultaneous colorectal liver metastases (CRLM) includes liver-directed chemotherapy, the resection of the CRLM, and the subsequent resection of the primary cancer. Retrospective data have shown that up to 80% of patients can successfully undergo a complete RM, whereas less than 30% of those undergoing classical management (CM) do so. This registry-based study compared the 2 approaches. Methods: The study was based on the LiverMetSurvey (January 1, 2000 to December 31, 2010) and included patients with 2 or more metastases. All patients had irinotecan and/or oxaliplatin-based chemotherapy before liver surgery. Patients undergoing simultaneous liver and colorectal surgery were excluded. Results: A total of 787 patients were included: 729 in the CM group and 58 in the RM group. Patients in the 2 groups had similar numbers of metastases (4.20 vs 4.80 for RM and CM, P = 0.231) and Fong scores of 3 or more (79% vs 87%, P = 0.164). Rectal cancer, neoadjuvant rectal radiotherapy, and the use of combined irinotecan/oxaliplatin chemotherapy were more frequent in the RM group (P < 0.001), whereas colorectal lymph node involvement was more frequent in the CM group (P < 0.001). Overall survival and disease-free survival were similar in the RM and CM groups (48% vs 46% at 5 years, P = 0.965 and 30% vs 26%, P = 0.992). Conclusions: Classical and reversed managements of metastatic liver disease in colorectal cancer are associated with similar survival when successfully completed. Liver-first reversed management for the treatment of patients with colorectal cancer and simultaneous liver metastases (CRLM) includes liver-directed chemotherapy, the resection of the CRLM, and the subsequent resection of the primary cancer. Classical and reversed managements of metastatic liver disease in colorectal cancer are associated with similar survival when successfully completed." @default.
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• W2074903169 date "2012-11-01" @default.
• W2074903169 modified "2023-10-18" @default.
• W2074903169 title "A Survival Analysis of the Liver-First Reversed Management of Advanced Simultaneous Colorectal Liver Metastases" @default.
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• W2074903169 doi "https://doi.org/10.1097/sla.0b013e3182734423" @default.
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