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- W2074906159 abstract "Airway inflammation is the main pathophysiological feature of patients with chronic obstructive pulmonary disease (COPD). Interleukin-8 (IL-8) is a potent chemoattractant for neutrophils and eosinophils. Increased IL-8 levels were observed in bronchoalveolar lavage (BAL) and induced sputum in patients with COPD. To evaluate the role of the IL-8 gene, we genotyped blood samples of 122 COPD-patients and 385 healthy controls for a known polymorphism in the promoter region (-251 A/T) of the IL-8 gene. Additionally, we screened the coding region for further polymorphisms by SSCP analyses. Comparison of the allele and genotype frequencies among each group revealed no significant differences between patients and controls. Although IL-8 plays an important role in the chemotaxis of inflammatory cells, the polymorphisms investigated here do not seem to be involved in the genetic predisposition to COPD." @default.
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- W2074906159 date "2005-08-01" @default.
- W2074906159 modified "2023-09-26" @default.
- W2074906159 title "Polymorphisms in theinterleukin-8 gene in patients with chronic obstructive pulmonary disease" @default.
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- W2074906159 doi "https://doi.org/10.1002/elps.200500095" @default.
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