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- W2074906979 abstract "With the advent of high-throughput gene perturbation screens (e.g., RNAi assays, genome-wide deletion mutants), modeling the complex relationship between genes and phenotypes has become a paramount problem. One broad class of methods uses 'guilt by association' methods to impute phenotypes to genes based on the interactions between the given gene and other genes with known phenotypes. But these methods are inadequate for genes that have no cataloged interactions but which nevertheless are known to result in important phenotypes. In this paper, we present an approach to first model relationships between phenotypes using the notion of 'relative importance' and subsequently use these derived relationships to make phenotype predictions. Besides improved accuracy on S. cerevisiae deletion mutants and C. elegans knock-down datasets, we show how our approach sheds insight into relations between phenotypes." @default.
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- W2074906979 date "2008-08-01" @default.
- W2074906979 modified "2023-09-27" @default.
- W2074906979 title "USING RELATIVE IMPORTANCE METHODS TO MODEL HIGH-THROUGHPUT GENE PERTURBATION SCREENS" @default.
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- W2074906979 doi "https://doi.org/10.1142/9781848162648_0020" @default.
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