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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074908177> ?p ?o ?g. }

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• W2074908177 abstract "There is an urgent need for the development of new drugs to treat Chagas' disease, which is caused by the protozoan parasite Trypanosoma cruzi. The enzyme dihydrofolate reductase (DHFR) has been a very successful drug target in a number of diseases and we decided to investigate it as a potential drug target for Chagas' disease. A homology model of the enzyme was used to search the Cambridge Structural Database using the program dock 3.5. Compounds were then tested against the enzyme and the whole parasite. Compounds were also screened against the related parasite, Trypanosoma brucei." @default.
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• W2074908177 date "2001-05-01" @default.
• W2074908177 modified "2023-10-05" @default.
• W2074908177 title "Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase" @default.
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• W2074908177 doi "https://doi.org/10.1016/s0223-5234(01)01235-1" @default.
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