FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074912991> ?p ?o ?g. }

• W2074912991 endingPage "1128" @default.
• W2074912991 startingPage "1123" @default.
• W2074912991 abstract "1. Neutrophil accumulation is a characteristic feature of the inflammatory response in myocardial tissue which has undergone a period of ischaemia. The aim of this study was to examine whether inhibition of myocardial neutrophil infiltration, using an antibody to the CD18 leukocyte adhesion molecule, was effective in reducing infarct size in anaesthetized rabbits. 2. Anaesthetized rabbits underwent coronary artery occlusion (CAO) for periods of 30 or 45 min followed by reperfusion for 3 h. Animals were treated intravenously 10 min prior to reperfusion with IB4, a monoclonal antibody to CD18 (1 mg kg-1) or saline (1 ml kg-1). In one group undergoing 45 min CAO, a control antibody, OKMI (1 mg kg-1) was given. 3. Following either 30 or 45 min of CAO, administration of IB4 resulted in a < 75% inhibition in neutrophil accumulation in the area at risk myocardium (AR) compared with control animals. 4. With the 30 min occlusion period, IB4 significantly reduced myocardial infarct size, 27.2 +/- 3.2% vs 67.4 +/- 5.6% in the saline control group (n = 5 P < 0.01). In contrast, IB4 did not reduce infarct size following a 45 min period of ischaemia. 5. In the same animals administration of IB4 significantly inhibited oedema formation in skin elicited by intradermal administration of the neutrophil chemoattractant f-Met-Leu-Phe, but had no effect on coronary microvascular plasma protein leakage in the AR. 6. Our results indicate that infiltrating neutrophils exacerbate tissue injury following a relatively short, 30 min period of myocardial ischaemia in the rabbit. However, protection with IB4 was no longer seen if the period of CAO was extended to 45 min. The results in this model suggest neutrophils are not a major determinant of tissue injury following more than a very short period of ischaemia." @default.
• W2074912991 created "2016-06-24" @default.
• W2074912991 creator A5033052914 @default.
• W2074912991 creator A5054779890 @default.
• W2074912991 creator A5060171155 @default.
• W2074912991 creator A5064628079 @default.
• W2074912991 date "1994-04-01" @default.
• W2074912991 modified "2023-09-26" @default.
• W2074912991 title "Effect of duration of ischaemia on reduction of myocardial infarct size by inhibition of neutrophil accumulation using an anti-CD18 monoclonal antibody" @default.
• W2074912991 cites W1593349322 @default.
• W2074912991 cites W1611385761 @default.
• W2074912991 cites W1890393137 @default.
• W2074912991 cites W1973185152 @default.
• W2074912991 cites W1989851755 @default.
• W2074912991 cites W1999730887 @default.
• W2074912991 cites W2001898552 @default.
• W2074912991 cites W2002475242 @default.
• W2074912991 cites W2009375475 @default.
• W2074912991 cites W2011513090 @default.
• W2074912991 cites W2014791861 @default.
• W2074912991 cites W2035211353 @default.
• W2074912991 cites W2043205372 @default.
• W2074912991 cites W2052327108 @default.
• W2074912991 cites W2059829735 @default.
• W2074912991 cites W2067264620 @default.
• W2074912991 cites W2070364693 @default.
• W2074912991 cites W2076989520 @default.
• W2074912991 cites W2096265656 @default.
• W2074912991 cites W2115654053 @default.
• W2074912991 cites W2132957787 @default.
• W2074912991 cites W2141211759 @default.
• W2074912991 cites W2145416006 @default.
• W2074912991 cites W2145432598 @default.
• W2074912991 cites W2146456660 @default.
• W2074912991 cites W2151067784 @default.
• W2074912991 cites W2259392365 @default.
• W2074912991 cites W2336628795 @default.
• W2074912991 cites W2405287729 @default.
• W2074912991 cites W2433556473 @default.
• W2074912991 cites W4214589643 @default.
• W2074912991 cites W4379136709 @default.
• W2074912991 cites W74321967 @default.
• W2074912991 doi "https://doi.org/10.1111/j.1476-5381.1994.tb14861.x" @default.
• W2074912991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1910128" @default.
• W2074912991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7913371" @default.
• W2074912991 hasPublicationYear "1994" @default.
• W2074912991 type Work @default.
• W2074912991 sameAs 2074912991 @default.
• W2074912991 citedByCount "47" @default.
• W2074912991 countsByYear W20749129912014 @default.
• W2074912991 countsByYear W20749129912015 @default.
• W2074912991 countsByYear W20749129912016 @default.
• W2074912991 countsByYear W20749129912021 @default.
• W2074912991 countsByYear W20749129912022 @default.
• W2074912991 crossrefType "journal-article" @default.
• W2074912991 hasAuthorship W2074912991A5033052914 @default.
• W2074912991 hasAuthorship W2074912991A5054779890 @default.
• W2074912991 hasAuthorship W2074912991A5060171155 @default.
• W2074912991 hasAuthorship W2074912991A5064628079 @default.
• W2074912991 hasBestOaLocation W20749129912 @default.
• W2074912991 hasConcept C126322002 @default.
• W2074912991 hasConcept C159654299 @default.
• W2074912991 hasConcept C164705383 @default.
• W2074912991 hasConcept C203014093 @default.
• W2074912991 hasConcept C2776820930 @default.
• W2074912991 hasConcept C2777397205 @default.
• W2074912991 hasConcept C2780393670 @default.
• W2074912991 hasConcept C42219234 @default.
• W2074912991 hasConcept C500558357 @default.
• W2074912991 hasConcept C53122370 @default.
• W2074912991 hasConcept C541997718 @default.
• W2074912991 hasConcept C542903549 @default.
• W2074912991 hasConcept C71924100 @default.
• W2074912991 hasConceptScore W2074912991C126322002 @default.
• W2074912991 hasConceptScore W2074912991C159654299 @default.
• W2074912991 hasConceptScore W2074912991C164705383 @default.
• W2074912991 hasConceptScore W2074912991C203014093 @default.
• W2074912991 hasConceptScore W2074912991C2776820930 @default.
• W2074912991 hasConceptScore W2074912991C2777397205 @default.
• W2074912991 hasConceptScore W2074912991C2780393670 @default.
• W2074912991 hasConceptScore W2074912991C42219234 @default.
• W2074912991 hasConceptScore W2074912991C500558357 @default.
• W2074912991 hasConceptScore W2074912991C53122370 @default.
• W2074912991 hasConceptScore W2074912991C541997718 @default.
• W2074912991 hasConceptScore W2074912991C542903549 @default.
• W2074912991 hasConceptScore W2074912991C71924100 @default.
• W2074912991 hasIssue "4" @default.
• W2074912991 hasLocation W20749129911 @default.
• W2074912991 hasLocation W20749129912 @default.
• W2074912991 hasLocation W20749129913 @default.
• W2074912991 hasLocation W20749129914 @default.
• W2074912991 hasOpenAccess W2074912991 @default.
• W2074912991 hasPrimaryLocation W20749129911 @default.
• W2074912991 hasRelatedWork W2008851126 @default.
• W2074912991 hasRelatedWork W2028222475 @default.
• W2074912991 hasRelatedWork W2049397185 @default.
• W2074912991 hasRelatedWork W2110542277 @default.
• W2074912991 hasRelatedWork W2363097030 @default.

• next