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• W2074920285 abstract "No AccessJournal of UrologyInvestigative Urology1 Feb 1997Stress-Induced Bladder Mast Cell Activation: Implications for Interstitial Cystitis Constantine Spanos, Xinzhu Pang, Konstantinos Ligris, Richard Letourneau, Lisa Alferes, Nicholas Alexacos, Grannum R. Sant, and Theoharis C. Theoharides Constantine SpanosConstantine Spanos More articles by this author , Xinzhu PangXinzhu Pang More articles by this author , Konstantinos LigrisKonstantinos Ligris More articles by this author , Richard LetourneauRichard Letourneau More articles by this author , Lisa AlferesLisa Alferes More articles by this author , Nicholas AlexacosNicholas Alexacos More articles by this author , Grannum R. SantGrannum R. Sant More articles by this author , and Theoharis C. TheoharidesTheoharis C. Theoharides More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65247-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To investigate whether acute psychological stress may activate bladder mast cells which appear to play a significant role in the pathophysiology of interstitial cystitis, a syndrome that occurs primarily in females and is characterized by urinary urgency, frequency and suprapubic pain, all of which often worsen with stress. Materials and Methods: Non-traumatic immobilization stress was used as a model of acute emotional stress by placing a rat in a plexiglass immobilizer, after first bringing each rat in the laboratory daily for 4 days to reduce the stress of handling. The rat was then anesthetized, decapitated and the bladder removed and fixed for light and electron microscopy. Results: This type of stress resulted in activation of over 70% of bladder mast cells within 30 minutes, as evidenced by light and electron microscopy. Pretreatment of the animals with intraperitoneal administration of polyclonal antiserum to corticotropin releasing hormone had no effect on bladder mast cell activation and no nerve fibers positive for this hormone were identified in the bladder. Stress-induced bladder mast cell activation was, however, substantially reduced in animals treated neonatally with capsaicin suggesting that sensory neuropeptides, such as substance P, of which increased positive nerve fibers have been localized close to bladder mast cells, are involved in this response. Conclusions: This is the first time that psychological stress is shown to activate bladder mast cells, apparently via the action of at least some sensory neuropeptides. These findings have implications for the pathophysiology and possible therapy of interstitial cystitis. 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Google Scholar Department of Pharmacology and Experimental Therapeutics, and Urology, Tufts University School of Medicine - New England Medical Center, Boston, Massachusetts.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byOottamasathien S, Jia W, Roundy L, Zhang J, Wang L, Ye X, Hill A, Savage J, Lee W, Hannon A, Milner S and Prestwich G (2013) Physiological Relevance of LL-37 Induced Bladder Inflammation and Mast CellsJournal of Urology, VOL. 190, NO. 4S, (1596-1602), Online publication date: 1-Oct-2013.Stav K, Lang E, Fanus Z and Leibovici D (2012) Autonomic Response During Bladder Hydrodistention in Patients with Bladder Pain SyndromeJournal of Urology, VOL. 188, NO. 1, (117-121), Online publication date: 1-Jul-2012.Pontari M and Ruggieri M (2018) Mechanisms in Prostatitis/Chronic Pelvic Pain SyndromeJournal of Urology, VOL. 179, NO. 5S, (S61-S67), Online publication date: 1-May-2008.Cao J, Boucher W, Kempuraj D, Donelan J and Theoharides T (2018) Acute Stress and Intravesical Corticotropin-Releasing Hormone Induces Mast Cell Dependent Vascular Endothelial Growth Factor Release From Mouse Bladder ExplantsJournal of Urology, VOL. 176, NO. 3, (1208-1213), Online publication date: 1-Sep-2006.ÇETINEL Ş, ERCAN F, ÇIKLER E, CONTUK G and ŞENER G (2018) PROTECTIVE EFFECT OF MELATONIN ON WATER AVOIDANCE STRESS INDUCED DEGENERATION OF THE BLADDERJournal of Urology, VOL. 173, NO. 1, (267-270), Online publication date: 1-Jan-2005.PONTARI M and RUGGIERI M (2018) MECHANISMS IN PROSTATITIS/CHRONIC PELVIC PAIN SYNDROMEJournal of Urology, VOL. 172, NO. 3, (839-845), Online publication date: 1-Sep-2004.Buffington C, Teng B and Somogyi G (2018) Norepinephrine Content And Adrenoceptor Function In The Bladder Of Cats With Feline Interstitial CystitisJournal of Urology, VOL. 167, NO. 4, (1876-1880), Online publication date: 1-Apr-2002.WESTROPP J and BUFFINGTON C (2018) IN VIVO MODELS OF INTERSTITIAL CYSTITISJournal of Urology, VOL. 167, NO. 2 Part 1, (694-702), Online publication date: 1-Feb-2002.BOUCHER W, LETOURNEAU R, HUANG M, KEMPURAJ D, GREEN M, SANT G and THEOHARIDES T (2018) INTRAVESICAL SODIUM HYALURONATE INHIBITS THE RAT URINARY MAST CELL MEDIATOR INCREASE TRIGGERED BY ACUTE IMMOBILIZATION STRESSJournal of Urology, VOL. 167, NO. 1, (380-384), Online publication date: 1-Jan-2002.ERCAN F, OKTAY S and ERIN N (2018) ROLE OF AFFERENT NEURONS IN STRESS INDUCED DEGENERATIVE CHANGES OF THE BLADDERJournal of Urology, VOL. 165, NO. 1, (235-239), Online publication date: 1-Jan-2001.CHIANG G, PATRA P, LETOURNEAU R, JEUDY S, BOUCHER W, GREEN M, SANT G and THEOHARIDES T (2018) PENTOSANPOLYSULFATE INHIBITS MAST CELL HISTAMINE SECRETION AND INTRACELLULAR CALCIUM ION LEVELS:: AN ALTERNATIVE EXPLANATION OF ITS BENEFICIAL EFFECT IN INTERSTITIAL CYSTITISJournal of Urology, VOL. 164, NO. 6, (2119-2125), Online publication date: 1-Dec-2000.LUTGENDORF S, KREDER K, ROTHROCK N, RATLIFF T and ZIMMERMAN B (2018) STRESS AND SYMPTOMATOLOGY IN PATIENTS WITH INTERSTITIAL CYSTITIS: A LABORATORY STRESS MODELJournal of Urology, VOL. 164, NO. 4, (1265-1269), Online publication date: 1-Oct-2000.JASMIN L, JANNI G, OHARA P and RABKIN S (2018) CNS INDUCED NEUROGENIC CYSTITIS IS ASSOCIATED WITH BLADDER MAST CELL DEGRANULATION IN THE RATJournal of Urology, VOL. 164, NO. 3 Part 1, (852-855), Online publication date: 1-Sep-2000. Volume 157Issue 2February 1997Page: 669-672 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.Metrics Author Information Constantine Spanos More articles by this author Xinzhu Pang More articles by this author Konstantinos Ligris More articles by this author Richard Letourneau More articles by this author Lisa Alferes More articles by this author Nicholas Alexacos More articles by this author Grannum R. Sant More articles by this author Theoharis C. Theoharides More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2074920285 title "Stress-Induced Bladder Mast Cell Activation: Implications for Interstitial Cystitis" @default.
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