Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074920586> ?p ?o ?g. }
- W2074920586 endingPage "96" @default.
- W2074920586 startingPage "71" @default.
- W2074920586 abstract "Strong efforts are being made in order to better understand the molecular mechanisms underlying cancer dissemination. We have attempted to summarise some of the findings in this area. A large number of differences in gene expression have been described in metastatic and non-metastatic cells. In the mouse B16 melanoma system, more than 50 different markers have been described. It is likely that many of these differences reflect the same genetic alteration (i.e. a mutation in a regulatory gene alters the expression of a set of co-regulated target genes). One could argue that it is more effective to study mutations in regulatory as opposed to expression of down-stream target genes. However, we feel that proto-oncogenes are less suitable as markers compared to target genes, since it is difficult to screen for mutations at multiple levels in regulatory pathways. In contrast, measuring the expression of a small number of target genes (i.e. one of the targets in Fig. 1), the expression of which are stimulated by upstream regulators, is accomplished more easily. It is anticipated that the future of optimised panels of independent markers will sharpen cancer diagnosis and lead to individualised therapy." @default.
- W2074920586 created "2016-06-24" @default.
- W2074920586 creator A5020831595 @default.
- W2074920586 creator A5024309803 @default.
- W2074920586 date "1996-10-01" @default.
- W2074920586 modified "2023-09-27" @default.
- W2074920586 title "The metastatic phenotype—prognostic implications" @default.
- W2074920586 cites W1425979353 @default.
- W2074920586 cites W1493558477 @default.
- W2074920586 cites W1505763719 @default.
- W2074920586 cites W1516353866 @default.
- W2074920586 cites W1545495395 @default.
- W2074920586 cites W1553932831 @default.
- W2074920586 cites W1568436538 @default.
- W2074920586 cites W1593920002 @default.
- W2074920586 cites W1598762088 @default.
- W2074920586 cites W1602004990 @default.
- W2074920586 cites W1760393685 @default.
- W2074920586 cites W1799131074 @default.
- W2074920586 cites W1837651204 @default.
- W2074920586 cites W1882504833 @default.
- W2074920586 cites W1899945956 @default.
- W2074920586 cites W1964140996 @default.
- W2074920586 cites W1964595762 @default.
- W2074920586 cites W1964973685 @default.
- W2074920586 cites W1965116477 @default.
- W2074920586 cites W1967243795 @default.
- W2074920586 cites W1967251768 @default.
- W2074920586 cites W1967304777 @default.
- W2074920586 cites W1967608949 @default.
- W2074920586 cites W1968449757 @default.
- W2074920586 cites W1969245473 @default.
- W2074920586 cites W1969328947 @default.
- W2074920586 cites W1971381858 @default.
- W2074920586 cites W1973330153 @default.
- W2074920586 cites W1974069821 @default.
- W2074920586 cites W1974546829 @default.
- W2074920586 cites W1975253827 @default.
- W2074920586 cites W1977217898 @default.
- W2074920586 cites W1977292159 @default.
- W2074920586 cites W1977549713 @default.
- W2074920586 cites W1977620790 @default.
- W2074920586 cites W1978368163 @default.
- W2074920586 cites W1979390430 @default.
- W2074920586 cites W1979498831 @default.
- W2074920586 cites W1980108423 @default.
- W2074920586 cites W1980119671 @default.
- W2074920586 cites W1980637945 @default.
- W2074920586 cites W1981570640 @default.
- W2074920586 cites W1982475981 @default.
- W2074920586 cites W1984247829 @default.
- W2074920586 cites W1985528986 @default.
- W2074920586 cites W1985585224 @default.
- W2074920586 cites W1985651419 @default.
- W2074920586 cites W1985727076 @default.
- W2074920586 cites W1987563200 @default.
- W2074920586 cites W1989143807 @default.
- W2074920586 cites W1990430938 @default.
- W2074920586 cites W1990436227 @default.
- W2074920586 cites W1990583954 @default.
- W2074920586 cites W1991131571 @default.
- W2074920586 cites W1991962266 @default.
- W2074920586 cites W1992045438 @default.
- W2074920586 cites W1992094660 @default.
- W2074920586 cites W1993715195 @default.
- W2074920586 cites W1994613028 @default.
- W2074920586 cites W1994975139 @default.
- W2074920586 cites W1995406904 @default.
- W2074920586 cites W1995954397 @default.
- W2074920586 cites W1996449685 @default.
- W2074920586 cites W1998316947 @default.
- W2074920586 cites W1999083651 @default.
- W2074920586 cites W2000000541 @default.
- W2074920586 cites W2001258296 @default.
- W2074920586 cites W2001753204 @default.
- W2074920586 cites W2002951101 @default.
- W2074920586 cites W2003012091 @default.
- W2074920586 cites W2003962192 @default.
- W2074920586 cites W2004898879 @default.
- W2074920586 cites W2005092901 @default.
- W2074920586 cites W2007599495 @default.
- W2074920586 cites W2007780628 @default.
- W2074920586 cites W2007904495 @default.
- W2074920586 cites W2009240587 @default.
- W2074920586 cites W2009622347 @default.
- W2074920586 cites W2009997132 @default.
- W2074920586 cites W2010435021 @default.
- W2074920586 cites W2012848143 @default.
- W2074920586 cites W2012855221 @default.
- W2074920586 cites W2012965108 @default.
- W2074920586 cites W2015519364 @default.
- W2074920586 cites W2018565695 @default.
- W2074920586 cites W2018875909 @default.
- W2074920586 cites W2019707235 @default.
- W2074920586 cites W2019830639 @default.
- W2074920586 cites W2020083284 @default.
- W2074920586 cites W2020908761 @default.
- W2074920586 cites W2021198425 @default.