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- W2074920594 endingPage "233" @default.
- W2074920594 startingPage "225" @default.
- W2074920594 abstract "The medial hypothalamus, amygdala, and dorsal periaqueductal gray constitute the main neural substrates for the integration of aversive states in the brain. More recently, some regions of the mesencephalon, such as the superior and inferior colliculi have also been proposed as part of this system. In fact, fear-like behaviors often result when these sites are electrically or chemically stimulated. Both the behavioral and autonomic consequences of electrical stimulation of the mesencephalic tectum have been shown to be attenuated by minor tranquilizers, probably through enhancement of gamma-aminobutyric acid (GABA)-mediated neurotransmission, which exerts a tonic inhibitory control on the neural circuits responsible for the so-called defense behavior repertoire. Besides GABA, also 5-hydroxy tryptamine serotonin (5-HT), opioids, neuropeptides, histaminergic and excitatory amino acids have all been implicated in the regulation of anxiety-related behaviors induced by stimulation of midbrain tectum. Efforts have been made to characterize how these neurotransmitters interact with each other in the organization of these reactions to aversive stimulation. In this review, we summarize the evidence linking the brain's defense response systems to the concept of fear-anxiety. Furthermore, a case is made for the consideration of the relevance of this body of data to the search for the physiological underpinnings of depression and its consequences." @default.
- W2074920594 created "2016-06-24" @default.
- W2074920594 creator A5006949403 @default.
- W2074920594 creator A5061940282 @default.
- W2074920594 creator A5071365334 @default.
- W2074920594 creator A5078885951 @default.
- W2074920594 date "2003-02-01" @default.
- W2074920594 modified "2023-10-10" @default.
- W2074920594 title "The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations" @default.
- W2074920594 cites W1965295649 @default.
- W2074920594 cites W1966889241 @default.
- W2074920594 cites W1967318820 @default.
- W2074920594 cites W1970407112 @default.
- W2074920594 cites W1970843817 @default.
- W2074920594 cites W1971976715 @default.
- W2074920594 cites W1976290627 @default.
- W2074920594 cites W1976916607 @default.
- W2074920594 cites W1978150164 @default.
- W2074920594 cites W1979523705 @default.
- W2074920594 cites W1980701640 @default.
- W2074920594 cites W1984850745 @default.
- W2074920594 cites W1986924355 @default.
- W2074920594 cites W1989019771 @default.
- W2074920594 cites W1990141695 @default.
- W2074920594 cites W1990994983 @default.
- W2074920594 cites W1992488144 @default.
- W2074920594 cites W1994652495 @default.
- W2074920594 cites W1997538178 @default.
- W2074920594 cites W1998392208 @default.
- W2074920594 cites W1999444655 @default.
- W2074920594 cites W2000326263 @default.
- W2074920594 cites W2002768403 @default.
- W2074920594 cites W2002989721 @default.
- W2074920594 cites W2003061480 @default.
- W2074920594 cites W2003847276 @default.
- W2074920594 cites W2003991837 @default.
- W2074920594 cites W2010789384 @default.
- W2074920594 cites W2013250524 @default.
- W2074920594 cites W2016017742 @default.
- W2074920594 cites W2017877722 @default.
- W2074920594 cites W2018414163 @default.
- W2074920594 cites W2019281824 @default.
- W2074920594 cites W2021782673 @default.
- W2074920594 cites W2022531344 @default.
- W2074920594 cites W2024133387 @default.
- W2074920594 cites W2025337851 @default.
- W2074920594 cites W2025525365 @default.
- W2074920594 cites W2027398184 @default.
- W2074920594 cites W2030225289 @default.
- W2074920594 cites W2033159493 @default.
- W2074920594 cites W2033366852 @default.
- W2074920594 cites W2034022670 @default.
- W2074920594 cites W2036593857 @default.
- W2074920594 cites W2037043198 @default.
- W2074920594 cites W2043164992 @default.
- W2074920594 cites W2043210767 @default.
- W2074920594 cites W2043557913 @default.
- W2074920594 cites W2044258305 @default.
- W2074920594 cites W2044399304 @default.
- W2074920594 cites W2046625964 @default.
- W2074920594 cites W2048974598 @default.
- W2074920594 cites W2055608327 @default.
- W2074920594 cites W2056257424 @default.
- W2074920594 cites W2056701575 @default.
- W2074920594 cites W2057230705 @default.
- W2074920594 cites W2059795395 @default.
- W2074920594 cites W2059818152 @default.
- W2074920594 cites W2061422482 @default.
- W2074920594 cites W2067741364 @default.
- W2074920594 cites W2069741307 @default.
- W2074920594 cites W2070623386 @default.
- W2074920594 cites W2070966985 @default.
- W2074920594 cites W2072073556 @default.
- W2074920594 cites W2073663854 @default.
- W2074920594 cites W2076277826 @default.
- W2074920594 cites W2077196351 @default.
- W2074920594 cites W2080123327 @default.
- W2074920594 cites W2082091099 @default.
- W2074920594 cites W2082725316 @default.
- W2074920594 cites W2084986241 @default.
- W2074920594 cites W2087901892 @default.
- W2074920594 cites W2088098726 @default.
- W2074920594 cites W2088582596 @default.
- W2074920594 cites W2088945268 @default.
- W2074920594 cites W2090210197 @default.
- W2074920594 cites W2091276242 @default.
- W2074920594 cites W2091522010 @default.
- W2074920594 cites W2093670138 @default.
- W2074920594 cites W2093734160 @default.
- W2074920594 cites W2094399437 @default.
- W2074920594 cites W2095414254 @default.
- W2074920594 cites W2103629674 @default.
- W2074920594 cites W2113281603 @default.
- W2074920594 cites W2127452804 @default.
- W2074920594 cites W2128434727 @default.
- W2074920594 cites W2129250083 @default.
- W2074920594 cites W2134331909 @default.
- W2074920594 cites W2169047887 @default.