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- W2074923607 abstract "1 Isolated segments of bovine mesenteric lymphatic vessels were loaded with [3H]-noradrenaline and its efflux in response to field stimulation at 2 Hz (0.3 ms pulses, 1 min train) examined. 2 Isoprenaline (10−6m) increased evoked fractional 3H efflux (3H released as a percentage of total tissue 3H at the onset of stimulation) from its control value of 0.67 ± 0.09 to 1.2 ± 0.18% (s.e.mean; n = 5). 3 Propranolol (10−6 m) alone had no effect on evoked fractional 3H efflux but blocked the increase in transmitter overflow induced by isoprenaline (10−6 m). 4 In the presence of the α-adrenoceptor antagonist phentolamine (10−6 m) the facilitatory effect of isoprenaline (10−6 m) on transmitter efflux was enhanced. In 5 experiments isoprenaline increased evoked fractional 3H efflux from its control value of 1.07 ± 0.17 to 2.5 ± 0.37% when phentolamine was present. 5 Adrenaline (10−8 m) increased evoked fractional 3H efflux from its control value of 0.76 ± 0.09 to 1.13 ± 0.17% (n = 7). 6 These findings are consistent with the presence of presynaptic β-adrenoceptors in this preparation. There is no evidence that these receptors play any role in feedback regulation of transmitter release." @default.
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- W2074923607 title "β-adrenoceptor-mediated facilitation of [3H]-noradrenaline release from the intramural nerves of bovine mesenteric lymphatic vessels" @default.
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- W2074923607 doi "https://doi.org/10.1111/j.1476-5381.1989.tb11782.x" @default.
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