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- W2074944400 abstract "An 80-year-old man with long-standing Paget's disease of the bone was referred with a 12-month history of worsening leucopenia and thrombocytopenia, which were asymptomatic. At the time of his bone marrow examination a full blood count showed: Hb 12·2 g/dl, white cell count 2·8 × 109/l, neutrophil count 2·0 × 109/l and platelet count 87 × 109/l. Bone marrow aspiration was difficult and yielded an aparticulate, haemodilute sample. A trephine biopsy demonstrated highly abnormal bony architecture with disorganized remodelling. There were numerous conspicuous large osteoclasts occupying many of the resorption bays, which is typical of Paget's disease. The specimen also revealed extensive replacement of the intertrabecular spaces by connective tissue that was associated with grade 3 reticulin content. These features suggested that the cytopenias were caused by the reduced haemopoietic capacity in the marrow, as a result of Paget's disease-associated fibrosis. Although haemorrhage can complicate bone marrow examination in patients with Paget's disease of the bone, our procedure was uneventful. The patient's blood counts have remained stable over a 6-month follow-up period." @default.
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- W2074944400 date "2003-12-11" @default.
- W2074944400 modified "2023-10-17" @default.
- W2074944400 title "Abnormal osteoclasts and bone marrow fibrosis in Paget's disease of the bone" @default.
- W2074944400 doi "https://doi.org/10.1046/j.1365-2141.2003.04570.x" @default.
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