FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074948166> ?p ?o ?g. }

• W2074948166 endingPage "268" @default.
• W2074948166 startingPage "259" @default.
• W2074948166 abstract "Labdane diterpenoids have a broad spectrum of biological activities including antibacterial, antiviral and anti-inflammatory properties. However, little is known about their possible role in the apoptotic cell death machinery. Here, we report that hispanolone derivatives, a group of labdane diterpenoids, induce apoptosis in different tumor cell lines by activating caspase-8 with subsequent participation of mitochondrial signaling. Activation of caspase-8 by hispanolone derivatives was followed by a decrease in mitochondrial membrane potential, the release of apoptotic factors from mitochondria to the cytosol, and activation of caspases-9 and 3. Hispanolone derivatives also led to a time-dependent cleavage of Bid. Inhibition of caspase-8 abrogated these processes, suggesting that the death receptor pathway has a critical role in the apoptotic events induced by hispanolone derivatives. In addition, silencing death receptors with small interfering RNA s or pretreating cells with neutralizing antibodies to Fas ligand, tumor necrosis factor receptor 1 (TNF-R1), and TNF-α receptor 2 (TRAIL) inhibited diterpenoid-induced apoptosis, revealing it to be dependent on these death receptors. Interestingly, hispanolone derivatives had no effect on non-tumor cells. Consistently, in vivo bioluminescence imaging corroborates this antineoplasic effect, as hispanolone derivatives significantly decrease cancer growth in tumor xenograft assays. These data demostrate the antitumoral effects of hispanolone derivatives and provide relevant preclinical validation for the use of these compounds as potent therapeutic agents in cancer treatment." @default.
• W2074948166 created "2016-06-24" @default.
• W2074948166 creator A5019026451 @default.
• W2074948166 creator A5023246558 @default.
• W2074948166 creator A5031573079 @default.
• W2074948166 creator A5041733538 @default.
• W2074948166 creator A5053849461 @default.
• W2074948166 creator A5066264000 @default.
• W2074948166 creator A5076758205 @default.
• W2074948166 date "2012-02-06" @default.
• W2074948166 modified "2023-10-14" @default.
• W2074948166 title "Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives" @default.
• W2074948166 cites W1481925502 @default.
• W2074948166 cites W1491294744 @default.
• W2074948166 cites W1581870304 @default.
• W2074948166 cites W194759927 @default.
• W2074948166 cites W1968374939 @default.
• W2074948166 cites W1974166735 @default.
• W2074948166 cites W1974744750 @default.
• W2074948166 cites W1976641658 @default.
• W2074948166 cites W1983867416 @default.
• W2074948166 cites W1990917512 @default.
• W2074948166 cites W1991300200 @default.
• W2074948166 cites W1999637833 @default.
• W2074948166 cites W2000178617 @default.
• W2074948166 cites W2001555312 @default.
• W2074948166 cites W2006652614 @default.
• W2074948166 cites W2006854266 @default.
• W2074948166 cites W2019162634 @default.
• W2074948166 cites W2020518991 @default.
• W2074948166 cites W2021453781 @default.
• W2074948166 cites W2041163647 @default.
• W2074948166 cites W2062853648 @default.
• W2074948166 cites W2062868705 @default.
• W2074948166 cites W2067916786 @default.
• W2074948166 cites W2068588493 @default.
• W2074948166 cites W2082575834 @default.
• W2074948166 cites W2090048638 @default.
• W2074948166 cites W2090443758 @default.
• W2074948166 cites W2098962649 @default.
• W2074948166 cites W2135662322 @default.
• W2074948166 cites W2136972007 @default.
• W2074948166 doi "https://doi.org/10.1038/onc.2012.23" @default.
• W2074948166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22310289" @default.
• W2074948166 hasPublicationYear "2012" @default.
• W2074948166 type Work @default.
• W2074948166 sameAs 2074948166 @default.
• W2074948166 citedByCount "14" @default.
• W2074948166 countsByYear W20749481662012 @default.
• W2074948166 countsByYear W20749481662013 @default.
• W2074948166 countsByYear W20749481662015 @default.
• W2074948166 countsByYear W20749481662016 @default.
• W2074948166 countsByYear W20749481662017 @default.
• W2074948166 countsByYear W20749481662018 @default.
• W2074948166 countsByYear W20749481662019 @default.
• W2074948166 countsByYear W20749481662020 @default.
• W2074948166 countsByYear W20749481662022 @default.
• W2074948166 crossrefType "journal-article" @default.
• W2074948166 hasAuthorship W2074948166A5019026451 @default.
• W2074948166 hasAuthorship W2074948166A5023246558 @default.
• W2074948166 hasAuthorship W2074948166A5031573079 @default.
• W2074948166 hasAuthorship W2074948166A5041733538 @default.
• W2074948166 hasAuthorship W2074948166A5053849461 @default.
• W2074948166 hasAuthorship W2074948166A5066264000 @default.
• W2074948166 hasAuthorship W2074948166A5076758205 @default.
• W2074948166 hasBestOaLocation W20749481661 @default.
• W2074948166 hasConcept C121608353 @default.
• W2074948166 hasConcept C163421366 @default.
• W2074948166 hasConcept C170493617 @default.
• W2074948166 hasConcept C17991360 @default.
• W2074948166 hasConcept C190283241 @default.
• W2074948166 hasConcept C203014093 @default.
• W2074948166 hasConcept C28859421 @default.
• W2074948166 hasConcept C31573885 @default.
• W2074948166 hasConcept C48297814 @default.
• W2074948166 hasConcept C502942594 @default.
• W2074948166 hasConcept C54355233 @default.
• W2074948166 hasConcept C55493867 @default.
• W2074948166 hasConcept C86803240 @default.
• W2074948166 hasConcept C95444343 @default.
• W2074948166 hasConcept C96232424 @default.
• W2074948166 hasConcept C98424977 @default.
• W2074948166 hasConceptScore W2074948166C121608353 @default.
• W2074948166 hasConceptScore W2074948166C163421366 @default.
• W2074948166 hasConceptScore W2074948166C170493617 @default.
• W2074948166 hasConceptScore W2074948166C17991360 @default.
• W2074948166 hasConceptScore W2074948166C190283241 @default.
• W2074948166 hasConceptScore W2074948166C203014093 @default.
• W2074948166 hasConceptScore W2074948166C28859421 @default.
• W2074948166 hasConceptScore W2074948166C31573885 @default.
• W2074948166 hasConceptScore W2074948166C48297814 @default.
• W2074948166 hasConceptScore W2074948166C502942594 @default.
• W2074948166 hasConceptScore W2074948166C54355233 @default.
• W2074948166 hasConceptScore W2074948166C55493867 @default.
• W2074948166 hasConceptScore W2074948166C86803240 @default.
• W2074948166 hasConceptScore W2074948166C95444343 @default.
• W2074948166 hasConceptScore W2074948166C96232424 @default.
• W2074948166 hasConceptScore W2074948166C98424977 @default.

• next