Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074949512> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2074949512 endingPage "95" @default.
- W2074949512 startingPage "83" @default.
- W2074949512 abstract "Solute transport within articular cartilage is of central importance to tissue physiology, and may mediate effects of mechanical compression on cell metabolism. We therefore developed and applied a freeze-substitution method for fixation of cartilage explant disks which had been compressed axially during radial solute desorption. Dextrans were used as model solutes. Explant morphology was well preserved and nonequilibrium solute concentration distributions were stable for several hours at room temperature. For desorption from explants compressed statically to 0–46% strain, analysis of laser confocal images and comparison to a theoretical model permitted measurement of effective diffusivities. Results were consistent with previous studies suggesting a role for transport limitations in mediating the decreases of chondrocyte metabolic rates associated with static compression. In explants compressed dynamically (23±5% strain at 0.001 Hz), evidence was obtained for the augmentation of effective transport rate of 3 kDa dextrans by oscillatory interstitial fluid flows. This suggests that augmented solute transport may play a role in mediating the increases of chondrocyte metabolic rates associated with dynamic compression. Methods appear suitable for quantitative studies of transport within mechanically compressed cartilage-like tissues, and may be valuable for identification of loading environments which optimize solute transport in tissue engineering applications." @default.
- W2074949512 created "2016-06-24" @default.
- W2074949512 creator A5003974495 @default.
- W2074949512 creator A5013028112 @default.
- W2074949512 creator A5043081607 @default.
- W2074949512 creator A5082240219 @default.
- W2074949512 date "2002-07-01" @default.
- W2074949512 modified "2023-10-16" @default.
- W2074949512 title "Preservation and analysis of nonequilibrium solute concentration distributions within mechanically compressed cartilage explants" @default.
- W2074949512 cites W154044508 @default.
- W2074949512 cites W1978619076 @default.
- W2074949512 cites W1991987132 @default.
- W2074949512 cites W1992742409 @default.
- W2074949512 cites W1995256973 @default.
- W2074949512 cites W1997299213 @default.
- W2074949512 cites W2006038006 @default.
- W2074949512 cites W2023600752 @default.
- W2074949512 cites W2029357468 @default.
- W2074949512 cites W2040689386 @default.
- W2074949512 cites W2048577098 @default.
- W2074949512 cites W2060177572 @default.
- W2074949512 cites W2065130531 @default.
- W2074949512 cites W2072411856 @default.
- W2074949512 cites W2150392328 @default.
- W2074949512 cites W2186680027 @default.
- W2074949512 doi "https://doi.org/10.1016/s0165-022x(02)00051-9" @default.
- W2074949512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12204413" @default.
- W2074949512 hasPublicationYear "2002" @default.
- W2074949512 type Work @default.
- W2074949512 sameAs 2074949512 @default.
- W2074949512 citedByCount "27" @default.
- W2074949512 countsByYear W20749495122012 @default.
- W2074949512 countsByYear W20749495122014 @default.
- W2074949512 countsByYear W20749495122016 @default.
- W2074949512 countsByYear W20749495122018 @default.
- W2074949512 countsByYear W20749495122020 @default.
- W2074949512 crossrefType "journal-article" @default.
- W2074949512 hasAuthorship W2074949512A5003974495 @default.
- W2074949512 hasAuthorship W2074949512A5013028112 @default.
- W2074949512 hasAuthorship W2074949512A5043081607 @default.
- W2074949512 hasAuthorship W2074949512A5082240219 @default.
- W2074949512 hasConcept C105702510 @default.
- W2074949512 hasConcept C12554922 @default.
- W2074949512 hasConcept C136229726 @default.
- W2074949512 hasConcept C150394285 @default.
- W2074949512 hasConcept C157890192 @default.
- W2074949512 hasConcept C159985019 @default.
- W2074949512 hasConcept C162711632 @default.
- W2074949512 hasConcept C178790620 @default.
- W2074949512 hasConcept C180016635 @default.
- W2074949512 hasConcept C185592680 @default.
- W2074949512 hasConcept C192562407 @default.
- W2074949512 hasConcept C202751555 @default.
- W2074949512 hasConcept C2780550940 @default.
- W2074949512 hasConcept C2781403057 @default.
- W2074949512 hasConcept C55493867 @default.
- W2074949512 hasConcept C71924100 @default.
- W2074949512 hasConcept C86803240 @default.
- W2074949512 hasConceptScore W2074949512C105702510 @default.
- W2074949512 hasConceptScore W2074949512C12554922 @default.
- W2074949512 hasConceptScore W2074949512C136229726 @default.
- W2074949512 hasConceptScore W2074949512C150394285 @default.
- W2074949512 hasConceptScore W2074949512C157890192 @default.
- W2074949512 hasConceptScore W2074949512C159985019 @default.
- W2074949512 hasConceptScore W2074949512C162711632 @default.
- W2074949512 hasConceptScore W2074949512C178790620 @default.
- W2074949512 hasConceptScore W2074949512C180016635 @default.
- W2074949512 hasConceptScore W2074949512C185592680 @default.
- W2074949512 hasConceptScore W2074949512C192562407 @default.
- W2074949512 hasConceptScore W2074949512C202751555 @default.
- W2074949512 hasConceptScore W2074949512C2780550940 @default.
- W2074949512 hasConceptScore W2074949512C2781403057 @default.
- W2074949512 hasConceptScore W2074949512C55493867 @default.
- W2074949512 hasConceptScore W2074949512C71924100 @default.
- W2074949512 hasConceptScore W2074949512C86803240 @default.
- W2074949512 hasIssue "2" @default.
- W2074949512 hasLocation W20749495121 @default.
- W2074949512 hasLocation W20749495122 @default.
- W2074949512 hasOpenAccess W2074949512 @default.
- W2074949512 hasPrimaryLocation W20749495121 @default.
- W2074949512 hasRelatedWork W1480797633 @default.
- W2074949512 hasRelatedWork W1965971430 @default.
- W2074949512 hasRelatedWork W2039195542 @default.
- W2074949512 hasRelatedWork W2490525963 @default.
- W2074949512 hasRelatedWork W3113789775 @default.
- W2074949512 hasRelatedWork W3214112236 @default.
- W2074949512 hasRelatedWork W4232436370 @default.
- W2074949512 hasRelatedWork W4255318078 @default.
- W2074949512 hasRelatedWork W4313424032 @default.
- W2074949512 hasRelatedWork W74175366 @default.
- W2074949512 hasVolume "52" @default.
- W2074949512 isParatext "false" @default.
- W2074949512 isRetracted "false" @default.
- W2074949512 magId "2074949512" @default.
- W2074949512 workType "article" @default.