Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074949645> ?p ?o ?g. }
- W2074949645 endingPage "1551" @default.
- W2074949645 startingPage "1541" @default.
- W2074949645 abstract "The quality of immune responses induced by DNA vaccination depends on the site of DNA administration, the expression, and the properties of the encoded antigen. In the present study, we demonstrate that intravenous hydrodynamic HIV-1 envelope DNA injection resulted in high levels of expression of HIV-1 envelope antigen in the liver. When compared to the administration of DNA by i.n., i.d., i.m., and i.splenic routes, hydrodynamic vaccination induced, upon DNA boosting, levels of HIV-1 envelope-specific antibodies 40-fold higher than those elicited by the other routes tested. Hydrodynamic vaccination with 1 microg DNA induced higher humoral responses than 100 microg DNA given intramuscularly in the prime-boost regimen. High levels of envelope-specific IgG and IgA antibodies were induced in genital tract secretions after two doses of DNA followed by intranasal boosting with recombinant HIV-1 gp120 protein. Furthermore, two doses of 100 microg DNA generated interferon-gamma production in approximately 4.3+/-1.7% of CD8(+) splenocytes after in vitro stimulation with HIV-1 envelope peptides. These results demonstrate that DNA vaccines targeted to tissues with high proteosynthetic activity, such as the liver, results in enhanced immune responses." @default.
- W2074949645 created "2016-06-24" @default.
- W2074949645 creator A5011545196 @default.
- W2074949645 creator A5018217496 @default.
- W2074949645 creator A5021227129 @default.
- W2074949645 creator A5031087263 @default.
- W2074949645 creator A5061139747 @default.
- W2074949645 creator A5064720448 @default.
- W2074949645 creator A5068120078 @default.
- W2074949645 creator A5070363000 @default.
- W2074949645 creator A5091730504 @default.
- W2074949645 date "2008-03-01" @default.
- W2074949645 modified "2023-10-07" @default.
- W2074949645 title "Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses" @default.
- W2074949645 cites W1528520360 @default.
- W2074949645 cites W1551726079 @default.
- W2074949645 cites W1570965411 @default.
- W2074949645 cites W1594804329 @default.
- W2074949645 cites W1628484047 @default.
- W2074949645 cites W1839631757 @default.
- W2074949645 cites W1930403058 @default.
- W2074949645 cites W1966583738 @default.
- W2074949645 cites W1967660067 @default.
- W2074949645 cites W1970124724 @default.
- W2074949645 cites W1973458116 @default.
- W2074949645 cites W1975200253 @default.
- W2074949645 cites W1975957969 @default.
- W2074949645 cites W1978337555 @default.
- W2074949645 cites W1979002716 @default.
- W2074949645 cites W1990567434 @default.
- W2074949645 cites W1992847175 @default.
- W2074949645 cites W1994778927 @default.
- W2074949645 cites W1997677784 @default.
- W2074949645 cites W2000573426 @default.
- W2074949645 cites W2001605325 @default.
- W2074949645 cites W2003344929 @default.
- W2074949645 cites W2003588837 @default.
- W2074949645 cites W2005892111 @default.
- W2074949645 cites W2011826751 @default.
- W2074949645 cites W2014666927 @default.
- W2074949645 cites W2015988072 @default.
- W2074949645 cites W2019350996 @default.
- W2074949645 cites W2026153041 @default.
- W2074949645 cites W2027932780 @default.
- W2074949645 cites W2031433110 @default.
- W2074949645 cites W2032038251 @default.
- W2074949645 cites W2037024271 @default.
- W2074949645 cites W2037845050 @default.
- W2074949645 cites W2042476299 @default.
- W2074949645 cites W2042610523 @default.
- W2074949645 cites W2044465251 @default.
- W2074949645 cites W2055020116 @default.
- W2074949645 cites W2062422615 @default.
- W2074949645 cites W2080088004 @default.
- W2074949645 cites W2089387913 @default.
- W2074949645 cites W2094208778 @default.
- W2074949645 cites W2098781795 @default.
- W2074949645 cites W2101961263 @default.
- W2074949645 cites W2107140931 @default.
- W2074949645 cites W2112939215 @default.
- W2074949645 cites W2114791742 @default.
- W2074949645 cites W2123602858 @default.
- W2074949645 cites W2124493774 @default.
- W2074949645 cites W2126255146 @default.
- W2074949645 cites W2138634802 @default.
- W2074949645 cites W2140457265 @default.
- W2074949645 cites W2144023036 @default.
- W2074949645 cites W2146478787 @default.
- W2074949645 cites W2146704167 @default.
- W2074949645 cites W2153163225 @default.
- W2074949645 cites W2159465958 @default.
- W2074949645 cites W2164277615 @default.
- W2074949645 cites W2172643117 @default.
- W2074949645 cites W2305123591 @default.
- W2074949645 cites W2327204353 @default.
- W2074949645 cites W4241169271 @default.
- W2074949645 doi "https://doi.org/10.1016/j.vaccine.2008.01.035" @default.
- W2074949645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2323585" @default.
- W2074949645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18304708" @default.
- W2074949645 hasPublicationYear "2008" @default.
- W2074949645 type Work @default.
- W2074949645 sameAs 2074949645 @default.
- W2074949645 citedByCount "25" @default.
- W2074949645 countsByYear W20749496452012 @default.
- W2074949645 countsByYear W20749496452014 @default.
- W2074949645 countsByYear W20749496452015 @default.
- W2074949645 countsByYear W20749496452017 @default.
- W2074949645 countsByYear W20749496452019 @default.
- W2074949645 countsByYear W20749496452020 @default.
- W2074949645 countsByYear W20749496452021 @default.
- W2074949645 countsByYear W20749496452022 @default.
- W2074949645 crossrefType "journal-article" @default.
- W2074949645 hasAuthorship W2074949645A5011545196 @default.
- W2074949645 hasAuthorship W2074949645A5018217496 @default.
- W2074949645 hasAuthorship W2074949645A5021227129 @default.
- W2074949645 hasAuthorship W2074949645A5031087263 @default.
- W2074949645 hasAuthorship W2074949645A5061139747 @default.
- W2074949645 hasAuthorship W2074949645A5064720448 @default.