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- W2074952525 abstract "Ubiquitously distributed in different plant species, plant lectins are highly diverse carbohydrate-binding proteins of non-immune origin. They have interesting pharmacological activities and currently are of great interest to thousands of people working on biomedical research in cancer-related problems. It has been widely accepted that plant lectins affect both apoptosis and autophagy by modulating representative signalling pathways involved in Bcl-2 family, caspase family, p53, PI3K/Akt, ERK, BNIP3, Ras-Raf and ATG families, in cancer. Plant lectins may have a role as potential new anti-tumour agents in cancer drug discovery. Thus, here we summarize these findings on pathway- involved plant lectins, to provide a comprehensive perspective for further elucidating their potential role as novel anti-cancer drugs, with respect to both apoptosis and autophagy in cancer pathogenesis, and future therapy." @default.
- W2074952525 created "2016-06-24" @default.
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- W2074952525 date "2014-12-09" @default.
- W2074952525 modified "2023-10-16" @default.
- W2074952525 title "Plant lectins, from ancient sugar-binding proteins to emerging anti-cancer drugs in apoptosis and autophagy" @default.
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- W2074952525 doi "https://doi.org/10.1111/cpr.12155" @default.
- W2074952525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6496769" @default.
- W2074952525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25488051" @default.
- W2074952525 hasPublicationYear "2014" @default.
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