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• W2074953432 abstract "Abstract One developing maxillary second molar tooth-germ from a 5-day old golden hamster was transplanted into the cheek pouch of each of 41 5–7-week old hamsters of the same inbred strain. Host animals were killed at intervals from 4 days up to 24 weeks after transplantation. 86 per cent of the transplants survived to show signs of further growth and development, as assessed by additional formation of enamel and dentine matrix. Each surviving germ showed only mild infiltration by inflammatory cells. Soon after transplantation, the enamel organ partially degenerated, occasionally undergoing squamous metaplasia and cyst formation. Nevertheless, new enamel was deposited, mainly in the cervical region, by freshlydifferentiated ameloblasts. After irregular or cellular dentine deposition, regular tubular dentine reappeared. Approximately 50 per cent of the transplants cultivated for more than 3 weeks developed roots. Acellular and cellular cementum, woven and lamellar bone, and periodontal ligament were all found in relation to some formed roots. The dentinogenesis of a further 10 (out of 16) transplants was assessed by tetracycline hydrochloride administration (10 mg/kg wt) at weekly intervals for 6 weeks to label newlyformed dentine. These transplants showed 3–5 discrete fluorescent lines in coronal dentine; thus dentinogenesis in the transplants occurred in a normal incremental manner." @default.
• W2074953432 created "2016-06-24" @default.
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• W2074953432 date "1978-01-01" @default.
• W2074953432 modified "2023-09-24" @default.
• W2074953432 title "continued development of 5-day old tooth-germs transplanted to syngeneic hamster (Mesocricetus auratus) cheek pouch" @default.
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• W2074953432 doi "https://doi.org/10.1016/0003-9969(78)90110-3" @default.
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