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• W2074961029 abstract "Over 3% of human proteins contain single amino acid repeats (repeat-containing proteins, RCPs). Many repeats (homopeptides) localize to important proteins involved in transcription, and the expansion of certain repeats, in particular poly-Q and poly-A tracts, can also lead to the development of neurological diseases. Previous studies have suggested that the homopeptide makeup is a result of the presence of G+C-rich tracts in the encoding genes and that expansion occurs via replication slippage. Here, we have performed a large-scale genomic analysis of the variation of the genes encoding RCPs in 13 species and present these data in an online database (http://repeats.med.monash.edu.au/genetic_analysis/). This resource allows rapid comparison and analysis of RCPs, homopeptides, and their underlying genetic tracts across the eukaryotic species considered. We report three major findings. First, there is a bias for a small subset of codons being reiterated within homopeptides, and there is no G+C or A+T bias relative to the organism's transcriptome. Second, single base pair transversions from the homocodon are unusually common and may represent a mechanism of reducing the rate of homopeptide mutations. Third, homopeptides that are conserved across different species lie within regions that are under stronger purifying selection in contrast to nonconserved homopeptides." @default.
• W2074961029 created "2016-06-24" @default.
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• W2074961029 date "2007-06-13" @default.
• W2074961029 modified "2023-10-18" @default.
• W2074961029 title "RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins" @default.
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• W2074961029 doi "https://doi.org/10.1101/gr.6255407" @default.
• W2074961029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1899123" @default.
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