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- W2074963908 endingPage "887" @default.
- W2074963908 startingPage "875" @default.
- W2074963908 abstract "Ageing is associated with impaired immune responses to pathogens and vaccines. As described in this Review, ageing results in disrupted regulation of immune cell functions and innate immune receptor signalling, and in the establishment of a persistent pro-inflammatory milieu. The authors explain how this age-associated dysregulation might contribute to chronic inflammatory diseases in the elderly. As we age, the innate immune system becomes dysregulated and is characterized by persistent inflammatory responses that involve multiple immune and non-immune cell types and that vary depending on the cell activation state and tissue context. This ageing-associated basal inflammation, particularly in humans, is thought to be induced by several factors, including the reactivation of latent viral infections and the release of endogenous damage-associated ligands of pattern recognition receptors (PRRs). Innate immune cell functions that are required to respond to pathogens or vaccines, such as cell migration and PRR signalling, are also impaired in aged individuals. This immune dysregulation may affect conditions associated with chronic inflammation, such as atherosclerosis and Alzheimer's disease." @default.
- W2074963908 created "2016-06-24" @default.
- W2074963908 creator A5014118446 @default.
- W2074963908 creator A5021647734 @default.
- W2074963908 creator A5028923883 @default.
- W2074963908 date "2013-10-25" @default.
- W2074963908 modified "2023-10-16" @default.
- W2074963908 title "Age-dependent dysregulation of innate immunity" @default.
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