FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074964963> ?p ?o ?g. }

• W2074964963 endingPage "697" @default.
• W2074964963 startingPage "677" @default.
• W2074964963 abstract "1. Patch clamp techniques were used to study the action of external Cs+ and Ba2+ on adenosine 5'-triphosphate (ATP)-dependent K+ channels in sarcolemmal vesicles from frog skeletal muscle. Both ions block channels in a voltage-dependent fashion, block increasing with hyperpolarization. 2. The Cs+ block is flickery, mean unitary current being reduced and open-level noise increased. The concentration dependence is consistent with 1:1 binding, with a dissociation constant (Kd) of 4.1 mM at -62 mV. The Kd increases e-fold for a 20 mV depolarization. 3. The kinetics of Cs+ block were analysed by amplitude distribution analysis, and by measurement of the excess open-level variance. Both methods gave similar rate constants for blocking and unblocking; about 20 mM-1 ms-1 and 75 ms-1 at -62 mV. 4. All the voltage dependence of the Cs+ block appears to lie in the blocking reaction; unblocking is independent of voltage. 5. Ba2+ blocks with slower kinetics, so that blocking events can be resolved in single-channel records. Ba2+ reduces mean open time and causes long closings. 6. The blocking rate constant for Ba2+ was measured from the open times. It was about 1.7 mM-1 ms-1 at -62 mV and increased e-fold for a 40 mV hyperpolarization. The unblocking rate, measured from closed times, yielded a Kd of about 0.1 mM at -62 mV, in agreement with that measured from the reduction in open-state probability. 7. Our results suggest that Cs+ and Ba2+ block at sites within the channel, and provide evidence that the channel is a multi-ion pore." @default.
• W2074964963 created "2016-06-24" @default.
• W2074964963 creator A5009614520 @default.
• W2074964963 creator A5046272340 @default.
• W2074964963 creator A5085791068 @default.
• W2074964963 date "1988-11-01" @default.
• W2074964963 modified "2023-10-18" @default.
• W2074964963 title "The voltage-dependent block of ATP-sensitive potassium channels of frog skeletal muscle by caesium and barium ions." @default.
• W2074964963 cites W1828284097 @default.
• W2074964963 cites W1965554709 @default.
• W2074964963 cites W1971070994 @default.
• W2074964963 cites W1975893495 @default.
• W2074964963 cites W1978775427 @default.
• W2074964963 cites W1985770721 @default.
• W2074964963 cites W1991687968 @default.
• W2074964963 cites W1994505216 @default.
• W2074964963 cites W1994924615 @default.
• W2074964963 cites W1997511216 @default.
• W2074964963 cites W2003786384 @default.
• W2074964963 cites W2009667219 @default.
• W2074964963 cites W2012745501 @default.
• W2074964963 cites W2015426350 @default.
• W2074964963 cites W2018067600 @default.
• W2074964963 cites W2021711819 @default.
• W2074964963 cites W2024391578 @default.
• W2074964963 cites W2039425559 @default.
• W2074964963 cites W2040648798 @default.
• W2074964963 cites W2058535047 @default.
• W2074964963 cites W2064953660 @default.
• W2074964963 cites W2071637776 @default.
• W2074964963 cites W2086345475 @default.
• W2074964963 cites W2092010382 @default.
• W2074964963 cites W2099975374 @default.
• W2074964963 cites W2100282855 @default.
• W2074964963 cites W2114536638 @default.
• W2074964963 cites W2133464980 @default.
• W2074964963 cites W2146152598 @default.
• W2074964963 cites W2154627288 @default.
• W2074964963 cites W2162206314 @default.
• W2074964963 doi "https://doi.org/10.1113/jphysiol.1988.sp017355" @default.
• W2074964963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1190998" @default.
• W2074964963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3267155" @default.
• W2074964963 hasPublicationYear "1988" @default.
• W2074964963 type Work @default.
• W2074964963 sameAs 2074964963 @default.
• W2074964963 citedByCount "104" @default.
• W2074964963 countsByYear W20749649632012 @default.
• W2074964963 countsByYear W20749649632013 @default.
• W2074964963 countsByYear W20749649632015 @default.
• W2074964963 countsByYear W20749649632018 @default.
• W2074964963 countsByYear W20749649632019 @default.
• W2074964963 countsByYear W20749649632021 @default.
• W2074964963 countsByYear W20749649632023 @default.
• W2074964963 crossrefType "journal-article" @default.
• W2074964963 hasAuthorship W2074964963A5009614520 @default.
• W2074964963 hasAuthorship W2074964963A5046272340 @default.
• W2074964963 hasAuthorship W2074964963A5085791068 @default.
• W2074964963 hasBestOaLocation W20749649631 @default.
• W2074964963 hasConcept C113196181 @default.
• W2074964963 hasConcept C119599485 @default.
• W2074964963 hasConcept C12554922 @default.
• W2074964963 hasConcept C127413603 @default.
• W2074964963 hasConcept C131453863 @default.
• W2074964963 hasConcept C145148216 @default.
• W2074964963 hasConcept C178790620 @default.
• W2074964963 hasConcept C179104552 @default.
• W2074964963 hasConcept C185592680 @default.
• W2074964963 hasConcept C4141045 @default.
• W2074964963 hasConcept C43617362 @default.
• W2074964963 hasConcept C517785266 @default.
• W2074964963 hasConcept C542576722 @default.
• W2074964963 hasConcept C66974803 @default.
• W2074964963 hasConcept C71240020 @default.
• W2074964963 hasConcept C81370116 @default.
• W2074964963 hasConcept C86803240 @default.
• W2074964963 hasConceptScore W2074964963C113196181 @default.
• W2074964963 hasConceptScore W2074964963C119599485 @default.
• W2074964963 hasConceptScore W2074964963C12554922 @default.
• W2074964963 hasConceptScore W2074964963C127413603 @default.
• W2074964963 hasConceptScore W2074964963C131453863 @default.
• W2074964963 hasConceptScore W2074964963C145148216 @default.
• W2074964963 hasConceptScore W2074964963C178790620 @default.
• W2074964963 hasConceptScore W2074964963C179104552 @default.
• W2074964963 hasConceptScore W2074964963C185592680 @default.
• W2074964963 hasConceptScore W2074964963C4141045 @default.
• W2074964963 hasConceptScore W2074964963C43617362 @default.
• W2074964963 hasConceptScore W2074964963C517785266 @default.
• W2074964963 hasConceptScore W2074964963C542576722 @default.
• W2074964963 hasConceptScore W2074964963C66974803 @default.
• W2074964963 hasConceptScore W2074964963C71240020 @default.
• W2074964963 hasConceptScore W2074964963C81370116 @default.
• W2074964963 hasConceptScore W2074964963C86803240 @default.
• W2074964963 hasIssue "1" @default.
• W2074964963 hasLocation W20749649631 @default.
• W2074964963 hasLocation W20749649632 @default.
• W2074964963 hasLocation W20749649633 @default.
• W2074964963 hasOpenAccess W2074964963 @default.
• W2074964963 hasPrimaryLocation W20749649631 @default.

• next