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• W2074967909 abstract "Controversy persists regarding the optimal treatment of pediatric craniopharyngiomas.We performed a meta-analysis of reported series of transcranial (TC) and transsphenoidal (TS) surgery for pediatric craniopharyngiomas to determine whether comparisons between the outcomes in TS and TC approaches are valid.Online databases were searched for English-language articles reporting quantifiable outcome data published between 1990 and 2010 pertaining to the surgical treatment of pediatric craniopharyngiomas. Forty-eight studies describing 2955 patients having TC surgery and 13 studies describing 373 patients having TS surgery met inclusion criteria.Before surgery, patients who had TC surgery had less visual loss, more frequent hydrocephalus and increased intracranial pressure, larger tumors, and more suprasellar disease. After surgery, patients in the TC group had lower rates of gross total resection (GTR), more frequent recurrence after GTR, higher neurological morbidity, more frequent diabetes insipidus, less improvement, and greater deterioration in vision. There was no difference in operative mortality, obesity/hyperphagia, or overall survival percentages.Directly comparing outcomes after TC and TS surgery for pediatric craniopharyngiomas does not appear to be valid. Baseline differences in patients who underwent each approach create selection bias that may explain the improved rates of disease control and lower morbidity of TS resection. Although TS approaches are becoming increasingly used for smaller tumors and those primarily intrasellar, tumors more amenable to TC surgery include large tumors with significant lateral extension, those that engulf vascular structures, and those with significant peripheral calcification." @default.
• W2074967909 created "2016-06-24" @default.
• W2074967909 creator A5031389016 @default.
• W2074967909 creator A5040507938 @default.
• W2074967909 creator A5053967071 @default.
• W2074967909 date "2011-09-01" @default.
• W2074967909 modified "2023-10-16" @default.
• W2074967909 title "Surgical Management of Craniopharyngiomas in Children: Meta-analysis and Comparison of Transcranial and Transsphenoidal Approaches" @default.
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• W2074967909 doi "https://doi.org/10.1227/neu.0b013e31821a872d" @default.
• W2074967909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21499159" @default.
• W2074967909 hasPublicationYear "2011" @default.
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