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• W2074969495 endingPage "765" @default.
• W2074969495 startingPage "761" @default.
• W2074969495 abstract "Interactions between the enteric nervous system of the gut and the brain occur bidirectionally over sympathetic and parasympathetic pathways. Coordinated actions of the central, autonomic and enteric nervous systems modulate intestinal motor, sensory and secretory activities by neuromodulators, including 5-HT, noradrenaline and dopamine. 5-HT is an important signaling molecule in the brain–gut axis and the 5-HT released from enterochromaffin cells modulates peristaltic, secretory, vasodilatory, vagal and nociceptive reflexes. Irritable bowel syndrome is associated with altered motility, secretion and sensation; enteric 5-HT signaling may be defective in this disorder. In this editorial, recent data are reviewed and the potential for the development of pharmacologic intervention is assessed." @default.
• W2074969495 created "2016-06-24" @default.
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• W2074969495 date "2007-05-15" @default.
• W2074969495 modified "2023-09-27" @default.
• W2074969495 title "5-HT and the brain–gut axis: opportunities for pharmacologic intervention" @default.
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• W2074969495 doi "https://doi.org/10.1517/13543784.16.6.761" @default.
• W2074969495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17501688" @default.
• W2074969495 hasPublicationYear "2007" @default.
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