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- W2074976278 abstract "Eicosanoids mediate insect cellular immune responses, which depend largely on phenoloxidase (PO) activity. In plasma, PO is activated by the proteolytic cleavage of proPO, which is stored in oenocytoids, a specific hemocyte type, of the beet armyworm, Spodoptera exigua. Eicosanoids induce an acute cell lysis of oenocytoids, which releases proPO into the plasma. We investigated an intracellular signal pathway following a functional interaction of eicosanoid(s) to a putative membrane receptor. U-73122 (a specific inhibitor of phospholipase C) inhibited oenocytoid lysis of S. exigua significantly after bacterial infection. We concluded that oenocytoid lysis required a certain level of calcium ion because EGTA (a calcium chelator) treatment inhibited cell lysis. Two protein kinase C (PKC) inhibitors (staurosporine and calphostin C) significantly inhibited the oenocytoid lysis. Oenocytoid lysis was likely induced by Na+ entry and subsequent osmotic shock because juvenile hormone analog, pyriproxyfen, which activates Na+-K+ ATPase and induces subsequent cell shrinkage, antagonized the effect of eicosaniod on cell lysis. Furthermore, ouabain (a specific Na+ pump inhibitor) significantly inhibited oenocytoid lysis. These results suggest that eicosanoid mediates oenocytoid lysis by activating the intracellular PKC pathway." @default.
- W2074976278 created "2016-06-24" @default.
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- W2074976278 date "2009-12-01" @default.
- W2074976278 modified "2023-09-30" @default.
- W2074976278 title "Oenocytoid cell lysis to release prophenoloxidase is induced by eicosanoid via protein kinase C" @default.
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- W2074976278 doi "https://doi.org/10.1016/j.aspen.2009.08.001" @default.
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