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- W2074983969 abstract "The renal interstitial compartment, situated between basement membranes of epithelia and vessels, contains two contiguous cellular networks. One network is formed by interstitial fibroblasts, the second one by dendritic cells. Both are in intimate contact with each other. Fibroblasts are interconnected by junctions and connected to basement membranes of vessels and tubules by focal adhesions. Fibroblasts constitute the “skeleton” of the kidney. In the renal cortex, fibroblasts produce erythropoietin and are distinguished from other interstitial cells by their prominent F-actin cytoskeleton, abundance of rough endoplasmic reticulum, and by ecto-5′-nucleotidase expression in their plasma membrane. The resident dendritic cells belong to the mononuclear phagocyte system and fulfil a sentinel function. They are characterized by their expression of MHC class II and CD11c. The central situation of fibroblasts suggests that signals from tubules, vessels, and inflammatory cells converge in fibroblasts and elicit an integrated response. Following tubular damage and inflammatory signals fibroblasts proliferate, change to the myofibroblast phenotype and increase their collagen production, potentially resulting in renal fibrosis. The acquisition of a profibrotic phenotype by fibroblasts in renal diseases is generally considered a main causal event in the progression of chronic renal failure. However, it might also be seen as a repair process." @default.
- W2074983969 created "2016-06-24" @default.
- W2074983969 creator A5014785589 @default.
- W2074983969 creator A5021108972 @default.
- W2074983969 date "2008-06-25" @default.
- W2074983969 modified "2023-10-18" @default.
- W2074983969 title "The renal cortical interstitium: morphological and functional aspects" @default.
- W2074983969 cites W1505584712 @default.
- W2074983969 cites W1537094542 @default.
- W2074983969 cites W1770545369 @default.
- W2074983969 cites W1964538893 @default.
- W2074983969 cites W1968858781 @default.
- W2074983969 cites W1969451177 @default.
- W2074983969 cites W1969881686 @default.
- W2074983969 cites W1971361291 @default.
- W2074983969 cites W1972050454 @default.
- W2074983969 cites W1974771466 @default.
- W2074983969 cites W1975071038 @default.
- W2074983969 cites W1977314871 @default.
- W2074983969 cites W1982143675 @default.
- W2074983969 cites W1983132018 @default.
- W2074983969 cites W1984819552 @default.
- W2074983969 cites W1992805078 @default.
- W2074983969 cites W1993748744 @default.
- W2074983969 cites W2000837348 @default.
- W2074983969 cites W2003228704 @default.
- W2074983969 cites W2005610476 @default.
- W2074983969 cites W2010280514 @default.
- W2074983969 cites W2013537969 @default.
- W2074983969 cites W2014304646 @default.
- W2074983969 cites W2017946623 @default.
- W2074983969 cites W2021843623 @default.
- W2074983969 cites W2023443380 @default.
- W2074983969 cites W2023750944 @default.
- W2074983969 cites W2023819379 @default.
- W2074983969 cites W2026938778 @default.
- W2074983969 cites W2028414806 @default.
- W2074983969 cites W2031830203 @default.
- W2074983969 cites W2032150619 @default.
- W2074983969 cites W2035725566 @default.
- W2074983969 cites W2039026111 @default.
- W2074983969 cites W2039309643 @default.
- W2074983969 cites W2042447144 @default.
- W2074983969 cites W2042568013 @default.
- W2074983969 cites W2042633155 @default.
- W2074983969 cites W2045492979 @default.
- W2074983969 cites W2045892087 @default.
- W2074983969 cites W2048280250 @default.
- W2074983969 cites W2048516537 @default.
- W2074983969 cites W2051174713 @default.
- W2074983969 cites W2052543379 @default.
- W2074983969 cites W2055622930 @default.
- W2074983969 cites W2060522997 @default.
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- W2074983969 cites W2065638130 @default.
- W2074983969 cites W2078716109 @default.
- W2074983969 cites W2079676318 @default.
- W2074983969 cites W2084468121 @default.
- W2074983969 cites W2095337395 @default.
- W2074983969 cites W2095909670 @default.
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- W2074983969 cites W2103984309 @default.
- W2074983969 cites W2105457928 @default.
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- W2074983969 cites W2121207140 @default.
- W2074983969 cites W2124572189 @default.
- W2074983969 cites W2129122050 @default.
- W2074983969 cites W2137987629 @default.
- W2074983969 cites W2138216041 @default.
- W2074983969 cites W2145599614 @default.
- W2074983969 cites W2148184356 @default.
- W2074983969 cites W2154139584 @default.
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- W2074983969 cites W2164945237 @default.
- W2074983969 cites W2168622914 @default.
- W2074983969 cites W2168709045 @default.
- W2074983969 cites W2170880674 @default.
- W2074983969 cites W2299255011 @default.
- W2074983969 cites W2318993770 @default.
- W2074983969 cites W2334436350 @default.
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- W2074983969 doi "https://doi.org/10.1007/s00418-008-0452-5" @default.
- W2074983969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2491705" @default.
- W2074983969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18575881" @default.
- W2074983969 hasPublicationYear "2008" @default.
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