Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074985483> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2074985483 endingPage "296" @default.
- W2074985483 startingPage "292" @default.
- W2074985483 abstract "The purpose of this study was to assess the long-term benefit of isotretinoin in otherwise therapy-resistant acne. We also assessed risk factors which might influence the long-term outcome. We studied 88 patients (mean age 20.8 years), most of whom had suffered from acne for many years (mean 7.4 years). They received isotretinoin in an initial dose of 0.5 or 1.0 mg/kg/day. The dose was subsequently adjusted according to response and side-effects. Most patients only required 4 months' therapy to produce at least 85% clinical improvement. The patients were seen up to 10 years post-therapy (mean 9 years). Sixty-one patients were still virtually clear of disease. Of the others, 16% required further treatment with conventional antibiotics and 23% required a second course of isotretinoin. Of those who relapsed, 96% did so within 3 years of stopping therapy. The patients' age, sex, and duration of acne did not influence outcome. However, in patients with predominantly truncal acne, especially when severe, there was an increased incidence of relapse. Sebum excretion is known to correlate with acne severity, but the long-term degree of sebum suppression was found not to be related to relapse. The dose schedule, in particular cumulative dose, was an important factor in determining relapse rate. Those patients who received 0.5 mg/kg daily, or a cumulative dose of < 120 mg/kg, had a significantly higher relapse rate than patients receiving a larger dose. We did not elicit any long-term systemic or biochemical side-effects. We conclude that isotretinoin is a safe and effective therapy.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2074985483 created "2016-06-24" @default.
- W2074985483 creator A5015129348 @default.
- W2074985483 creator A5048797233 @default.
- W2074985483 creator A5063266899 @default.
- W2074985483 creator A5086273885 @default.
- W2074985483 date "1993-09-01" @default.
- W2074985483 modified "2023-10-14" @default.
- W2074985483 title "Isotretinoin for acne vulgaris-10 years later; a safe and successful treatment" @default.
- W2074985483 cites W1032597131 @default.
- W2074985483 cites W1561777399 @default.
- W2074985483 cites W1584295824 @default.
- W2074985483 cites W1968307580 @default.
- W2074985483 cites W1973337644 @default.
- W2074985483 cites W1975931900 @default.
- W2074985483 cites W1983745922 @default.
- W2074985483 cites W2017067817 @default.
- W2074985483 cites W2019160294 @default.
- W2074985483 cites W2020601786 @default.
- W2074985483 cites W2021557642 @default.
- W2074985483 cites W2024422870 @default.
- W2074985483 cites W2026971310 @default.
- W2074985483 cites W204609692 @default.
- W2074985483 cites W2049647488 @default.
- W2074985483 cites W2052188352 @default.
- W2074985483 cites W2055133589 @default.
- W2074985483 cites W2065618985 @default.
- W2074985483 cites W2092740507 @default.
- W2074985483 cites W2103760238 @default.
- W2074985483 doi "https://doi.org/10.1111/j.1365-2133.1993.tb11849.x" @default.
- W2074985483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8286227" @default.
- W2074985483 hasPublicationYear "1993" @default.
- W2074985483 type Work @default.
- W2074985483 sameAs 2074985483 @default.
- W2074985483 citedByCount "189" @default.
- W2074985483 countsByYear W20749854832012 @default.
- W2074985483 countsByYear W20749854832013 @default.
- W2074985483 countsByYear W20749854832014 @default.
- W2074985483 countsByYear W20749854832015 @default.
- W2074985483 countsByYear W20749854832016 @default.
- W2074985483 countsByYear W20749854832017 @default.
- W2074985483 countsByYear W20749854832018 @default.
- W2074985483 countsByYear W20749854832019 @default.
- W2074985483 countsByYear W20749854832020 @default.
- W2074985483 countsByYear W20749854832021 @default.
- W2074985483 countsByYear W20749854832022 @default.
- W2074985483 countsByYear W20749854832023 @default.
- W2074985483 crossrefType "journal-article" @default.
- W2074985483 hasAuthorship W2074985483A5015129348 @default.
- W2074985483 hasAuthorship W2074985483A5048797233 @default.
- W2074985483 hasAuthorship W2074985483A5063266899 @default.
- W2074985483 hasAuthorship W2074985483A5086273885 @default.
- W2074985483 hasConcept C120665830 @default.
- W2074985483 hasConcept C121332964 @default.
- W2074985483 hasConcept C126322002 @default.
- W2074985483 hasConcept C141071460 @default.
- W2074985483 hasConcept C151032500 @default.
- W2074985483 hasConcept C16005928 @default.
- W2074985483 hasConcept C2776285725 @default.
- W2074985483 hasConcept C2777673923 @default.
- W2074985483 hasConcept C61511704 @default.
- W2074985483 hasConcept C71924100 @default.
- W2074985483 hasConceptScore W2074985483C120665830 @default.
- W2074985483 hasConceptScore W2074985483C121332964 @default.
- W2074985483 hasConceptScore W2074985483C126322002 @default.
- W2074985483 hasConceptScore W2074985483C141071460 @default.
- W2074985483 hasConceptScore W2074985483C151032500 @default.
- W2074985483 hasConceptScore W2074985483C16005928 @default.
- W2074985483 hasConceptScore W2074985483C2776285725 @default.
- W2074985483 hasConceptScore W2074985483C2777673923 @default.
- W2074985483 hasConceptScore W2074985483C61511704 @default.
- W2074985483 hasConceptScore W2074985483C71924100 @default.
- W2074985483 hasIssue "3" @default.
- W2074985483 hasLocation W20749854831 @default.
- W2074985483 hasLocation W20749854832 @default.
- W2074985483 hasOpenAccess W2074985483 @default.
- W2074985483 hasPrimaryLocation W20749854831 @default.
- W2074985483 hasRelatedWork W1831466767 @default.
- W2074985483 hasRelatedWork W2027614408 @default.
- W2074985483 hasRelatedWork W2080436120 @default.
- W2074985483 hasRelatedWork W2091461711 @default.
- W2074985483 hasRelatedWork W2305922381 @default.
- W2074985483 hasRelatedWork W2563438566 @default.
- W2074985483 hasRelatedWork W2572390839 @default.
- W2074985483 hasRelatedWork W2789590115 @default.
- W2074985483 hasRelatedWork W2791757255 @default.
- W2074985483 hasRelatedWork W4385231871 @default.
- W2074985483 hasVolume "129" @default.
- W2074985483 isParatext "false" @default.
- W2074985483 isRetracted "false" @default.
- W2074985483 magId "2074985483" @default.
- W2074985483 workType "article" @default.