Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074990561> ?p ?o ?g. }
- W2074990561 endingPage "121" @default.
- W2074990561 startingPage "107" @default.
- W2074990561 abstract "Bone disease is one of the most common complications of multiple myeloma. It is the result of increased osteoclast activity which is not compensated by osteoblast activity and leads to osteolytic lesions characterized by bone pain and increased risk for pathological fracture, spinal cord compression and need for radiotherapy or surgery to the bone. Recent studies have revealed novel pathways and molecules that are involved in the biology of myeloma bone disease including the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin pathway, the Wnt signaling inhibitors dickkopf-1 and sclerostin, macrophage inflammatory proteins, activin A, and others. A thorough study of these pathways have provided novel agents that may play a critical role in the management of myeloma related bone disease in the near future, such as denosumab (anti-RANKL), sotatercept (activin A antagonist), romosozumab (anti-sclerostin) or BHQ-880 (anti-dickkopf 1). Currently, bisphosphonates are the cornerstone in the treatment of myeloma related bone disease. Zoledronic acid and pamidronate are used in this setting with very good results in reducing skeletal-related events, but they cannot be used in patients with severe renal impairment. Furthermore, they have some rare but serious adverse events including osteonecrosis of the jaw and acute renal insufficiency. This review paper focuses on the latest advances in the pathophysiology of myeloma bone disease and in the current and future treatment options for its management." @default.
- W2074990561 created "2016-06-24" @default.
- W2074990561 creator A5041407463 @default.
- W2074990561 creator A5047107290 @default.
- W2074990561 creator A5090085247 @default.
- W2074990561 date "2014-04-01" @default.
- W2074990561 modified "2023-09-27" @default.
- W2074990561 title "Biology and management of myeloma-related bone disease" @default.
- W2074990561 cites W1530002712 @default.
- W2074990561 cites W1532955823 @default.
- W2074990561 cites W1534557867 @default.
- W2074990561 cites W1534645474 @default.
- W2074990561 cites W1547160344 @default.
- W2074990561 cites W1552724609 @default.
- W2074990561 cites W1575059564 @default.
- W2074990561 cites W1580184585 @default.
- W2074990561 cites W1603660152 @default.
- W2074990561 cites W1932993947 @default.
- W2074990561 cites W1944559787 @default.
- W2074990561 cites W1958364130 @default.
- W2074990561 cites W1964048829 @default.
- W2074990561 cites W1964328292 @default.
- W2074990561 cites W1968090694 @default.
- W2074990561 cites W1971720206 @default.
- W2074990561 cites W1972705137 @default.
- W2074990561 cites W1973701188 @default.
- W2074990561 cites W1975549555 @default.
- W2074990561 cites W1976822899 @default.
- W2074990561 cites W1977013832 @default.
- W2074990561 cites W1979903598 @default.
- W2074990561 cites W1980391043 @default.
- W2074990561 cites W1983939760 @default.
- W2074990561 cites W1985645291 @default.
- W2074990561 cites W1985730473 @default.
- W2074990561 cites W1985919561 @default.
- W2074990561 cites W1988977449 @default.
- W2074990561 cites W1990781364 @default.
- W2074990561 cites W1992422220 @default.
- W2074990561 cites W1993479864 @default.
- W2074990561 cites W1994182611 @default.
- W2074990561 cites W1997686829 @default.
- W2074990561 cites W1998628488 @default.
- W2074990561 cites W1998854709 @default.
- W2074990561 cites W1999077925 @default.
- W2074990561 cites W2000096438 @default.
- W2074990561 cites W2000647744 @default.
- W2074990561 cites W2001670154 @default.
- W2074990561 cites W2002918019 @default.
- W2074990561 cites W2005830516 @default.
- W2074990561 cites W2006778528 @default.
- W2074990561 cites W2011926580 @default.
- W2074990561 cites W2012675589 @default.
- W2074990561 cites W2013322454 @default.
- W2074990561 cites W201366182 @default.
- W2074990561 cites W2017845136 @default.
- W2074990561 cites W2017849590 @default.
- W2074990561 cites W2022292514 @default.
- W2074990561 cites W2027352882 @default.
- W2074990561 cites W2030504185 @default.
- W2074990561 cites W2031314023 @default.
- W2074990561 cites W2031650256 @default.
- W2074990561 cites W2033294313 @default.
- W2074990561 cites W2034825504 @default.
- W2074990561 cites W2035237112 @default.
- W2074990561 cites W2036368043 @default.
- W2074990561 cites W2037591870 @default.
- W2074990561 cites W2038741802 @default.
- W2074990561 cites W2039215669 @default.
- W2074990561 cites W2039354268 @default.
- W2074990561 cites W2039888051 @default.
- W2074990561 cites W2040190064 @default.
- W2074990561 cites W2040436190 @default.
- W2074990561 cites W2043295936 @default.
- W2074990561 cites W2044794329 @default.
- W2074990561 cites W2044835347 @default.
- W2074990561 cites W2046390154 @default.
- W2074990561 cites W2048299560 @default.
- W2074990561 cites W2048994674 @default.
- W2074990561 cites W2049848179 @default.
- W2074990561 cites W2050567975 @default.
- W2074990561 cites W2050654453 @default.
- W2074990561 cites W2054956124 @default.
- W2074990561 cites W2055966182 @default.
- W2074990561 cites W2056684547 @default.
- W2074990561 cites W2057961407 @default.
- W2074990561 cites W2059459946 @default.
- W2074990561 cites W2063048904 @default.
- W2074990561 cites W2066000727 @default.
- W2074990561 cites W2066329342 @default.
- W2074990561 cites W2066639236 @default.
- W2074990561 cites W2067594973 @default.
- W2074990561 cites W2067723299 @default.
- W2074990561 cites W2070394208 @default.
- W2074990561 cites W2073944708 @default.
- W2074990561 cites W2077015738 @default.
- W2074990561 cites W2078400068 @default.
- W2074990561 cites W2078493291 @default.
- W2074990561 cites W2079007861 @default.