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• W2074996113 abstract "Although tremendous improvements have been implemented in current embryo culture systems, embryo wastage is still a major concern during extended culture. In most cases, the cause of repeated implantation failure (RIF) seems to be multifactorial, several studies have indicated a possible beneficial role of endometrial coculture systems on RIF cases via improving embryo quality and viability. Also, several studies are performed to overcome a possible contribution of chromosomal abnormalities on RIF by selecting the chromosomally abnormal embryos via preimplantation genetic diagnosis (PGD). This study is undertaken to analyze the cumulative contribution of endometrial coculture (EC) in such cases undergoing preimplantation genetic diagnosis (PGD). Retrospective Study Overall, 113 cycles in which PGD with the indication of recurrent implantation failure (n≥3) have been performed were included in the study between March 2001 and November 2004. Patients were retrospectively grouped according to culture media systems used. In 78 patients (group I) sequential media has been of choice throughout the culture period and in 35 cycles endometrial coculture has been utilized. From pre-zygote stage to embryo transfer, daily embryo growth parameters were scored and compared between groups. Blastomere biopsy was performed either on day 3 or day 4 and normal embryos after FISH analysis were selected for embryo transfer. No statistically significant difference in main patient and cycle parameters such as female age, male age, BMI, gonadotrophine ampoules used, MII oocytes collected and fertilized were found between groups (p>0.05). However, when embryo development characteristics were compared, faster cleavage on day 3 (74,8%) and improved viability with lower arrest rate after biopsy (14.6%) were observed in coculture group with respect to conventional culture media (62.4% and 21.7% respectively). Embryo growth and quality were also superior in endometrial coculture in comparison to previous cycles with conventional media in the same group of patients. Our results show that culturing embryos on endometrial monolayer cells seems to increase the cleavage rate and the quality of embryos in recurrent implantation failure cases. Furthermore, since increase in cleavage rate can also increase the number of embryos available for biopsy during preimplantation genetic diagnosis, culturing the embryos in endometrial coculture systems can improve the cycle outcome. Therefore, EC can be a successful alternative to conventional culture media in such cases where PGD is planned." @default.
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• W2074996113 date "2005-09-01" @default.
• W2074996113 modified "2023-09-27" @default.
• W2074996113 title "Endometrial Coculture: An Effective Culture System for Preimplantation Genetic Diagnosis?" @default.
• W2074996113 doi "https://doi.org/10.1016/j.fertnstert.2005.07.900" @default.
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