FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074996906> ?p ?o ?g. }

• W2074996906 endingPage "42" @default.
• W2074996906 startingPage "37" @default.
• W2074996906 abstract "Abstract Background The vasoconstrictor action of endothelin‐1 (ET‐1) is mediated through ET A and ET B receptor subtypes on vascular smooth muscle. ET B receptors are also present on the vascular endothelium where they mediate vasodilation. Animal studies suggest that the ET B receptor also acts as a clearance receptor for endothelin. Aims To investigate the effects of a selective ET A and a selective ET B receptor antagonist alone and in combination on haemodynamics and circulating concentrations of ET‐1 in patients with chronic heart failure. Results Infusion of BQ‐123 ( n =10), a selective ET A receptor antagonist, led to systemic vasodilation and did not change plasma ET‐1 concentrations (1.38±0.82 to 1.38±0.91 fmol/ml, ns). Infusion of BQ‐788 ( n =8) led to systemic vasoconstriction with a rise in plasma ET‐1 (1.84±1.06 to 2.73±0.99 fmol/ml, p <0.01). The addition of BQ‐123 to BQ‐788 led to systemic and pulmonary vasodilation with no further increase in plasma ET‐1 concentrations (2.80±1.14 to 2.90±1.20 fmol/ml, ns). Conclusion The rise in plasma ET‐1 concentrations in response to selective blockade of ET B receptors and the associated adverse haemodynamic effects suggest that ET B receptors have a role in the clearance of ET‐1 in man and that their blockade may not be advantageous for patients with heart failure." @default.
• W2074996906 created "2016-06-24" @default.
• W2074996906 creator A5017160240 @default.
• W2074996906 creator A5028116777 @default.
• W2074996906 creator A5034751596 @default.
• W2074996906 creator A5042811176 @default.
• W2074996906 creator A5049723954 @default.
• W2074996906 creator A5069418930 @default.
• W2074996906 date "2005-01-01" @default.
• W2074996906 modified "2023-10-13" @default.
• W2074996906 title "Comparison of selective ETAand ETBreceptor antagonists in patients with chronic heart failure" @default.
• W2074996906 cites W1813207029 @default.
• W2074996906 cites W1968412767 @default.
• W2074996906 cites W1969965845 @default.
• W2074996906 cites W1977343715 @default.
• W2074996906 cites W1979604318 @default.
• W2074996906 cites W1980665041 @default.
• W2074996906 cites W1992583442 @default.
• W2074996906 cites W1993972994 @default.
• W2074996906 cites W2003967661 @default.
• W2074996906 cites W2004601169 @default.
• W2074996906 cites W2039767184 @default.
• W2074996906 cites W2042526294 @default.
• W2074996906 cites W2043143761 @default.
• W2074996906 cites W2074113957 @default.
• W2074996906 cites W2086493734 @default.
• W2074996906 cites W2092022349 @default.
• W2074996906 cites W2093655696 @default.
• W2074996906 cites W2095914122 @default.
• W2074996906 cites W2102964489 @default.
• W2074996906 cites W2104825830 @default.
• W2074996906 cites W2104840130 @default.
• W2074996906 cites W2115374185 @default.
• W2074996906 cites W2117259028 @default.
• W2074996906 cites W2122271654 @default.
• W2074996906 cites W2138980497 @default.
• W2074996906 cites W2144128868 @default.
• W2074996906 cites W2148145053 @default.
• W2074996906 cites W2160097548 @default.
• W2074996906 cites W2162804111 @default.
• W2074996906 cites W2169494125 @default.
• W2074996906 cites W2243827514 @default.
• W2074996906 cites W2277403039 @default.
• W2074996906 doi "https://doi.org/10.1016/j.ejheart.2004.08.001" @default.
• W2074996906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15642529" @default.
• W2074996906 hasPublicationYear "2005" @default.
• W2074996906 type Work @default.
• W2074996906 sameAs 2074996906 @default.
• W2074996906 citedByCount "32" @default.
• W2074996906 countsByYear W20749969062012 @default.
• W2074996906 countsByYear W20749969062014 @default.
• W2074996906 countsByYear W20749969062016 @default.
• W2074996906 countsByYear W20749969062017 @default.
• W2074996906 crossrefType "journal-article" @default.
• W2074996906 hasAuthorship W2074996906A5017160240 @default.
• W2074996906 hasAuthorship W2074996906A5028116777 @default.
• W2074996906 hasAuthorship W2074996906A5034751596 @default.
• W2074996906 hasAuthorship W2074996906A5042811176 @default.
• W2074996906 hasAuthorship W2074996906A5049723954 @default.
• W2074996906 hasAuthorship W2074996906A5069418930 @default.
• W2074996906 hasConcept C120770815 @default.
• W2074996906 hasConcept C126322002 @default.
• W2074996906 hasConcept C134018914 @default.
• W2074996906 hasConcept C144980905 @default.
• W2074996906 hasConcept C149601957 @default.
• W2074996906 hasConcept C170493617 @default.
• W2074996906 hasConcept C178853913 @default.
• W2074996906 hasConcept C2776885963 @default.
• W2074996906 hasConcept C2778122271 @default.
• W2074996906 hasConcept C2778198053 @default.
• W2074996906 hasConcept C2778468042 @default.
• W2074996906 hasConcept C2779961880 @default.
• W2074996906 hasConcept C29323129 @default.
• W2074996906 hasConcept C71924100 @default.
• W2074996906 hasConcept C98274493 @default.
• W2074996906 hasConceptScore W2074996906C120770815 @default.
• W2074996906 hasConceptScore W2074996906C126322002 @default.
• W2074996906 hasConceptScore W2074996906C134018914 @default.
• W2074996906 hasConceptScore W2074996906C144980905 @default.
• W2074996906 hasConceptScore W2074996906C149601957 @default.
• W2074996906 hasConceptScore W2074996906C170493617 @default.
• W2074996906 hasConceptScore W2074996906C178853913 @default.
• W2074996906 hasConceptScore W2074996906C2776885963 @default.
• W2074996906 hasConceptScore W2074996906C2778122271 @default.
• W2074996906 hasConceptScore W2074996906C2778198053 @default.
• W2074996906 hasConceptScore W2074996906C2778468042 @default.
• W2074996906 hasConceptScore W2074996906C2779961880 @default.
• W2074996906 hasConceptScore W2074996906C29323129 @default.
• W2074996906 hasConceptScore W2074996906C71924100 @default.
• W2074996906 hasConceptScore W2074996906C98274493 @default.
• W2074996906 hasIssue "1" @default.
• W2074996906 hasLocation W20749969061 @default.
• W2074996906 hasLocation W20749969062 @default.
• W2074996906 hasOpenAccess W2074996906 @default.
• W2074996906 hasPrimaryLocation W20749969061 @default.
• W2074996906 hasRelatedWork W1968092735 @default.
• W2074996906 hasRelatedWork W1971056599 @default.
• W2074996906 hasRelatedWork W1978220856 @default.

• next