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- W2075003568 abstract "Preventive effects of dehydroepiandrosteone acetate (DHEA-A) and clofibrate (positive control substance) on the fatty liver induced by orotic acid (OA) were examined on the male Sprague-Dawley rats fed a high sucrose based diet containing 1% OA and this diet further mixed with 0.5% DHEA-A or 0.5% clofibrate for 2 weeks. Numerous lipid droplets were observed in the hepatocytes of the rats treated with OA alone, but not in those treated with DHEA-A or clofibrate. In comparison to the group with OA alone, the DHEA-A or clofibrate treated rats showed a larger relative liver weight (to body weight) which was accompanied by increased peroxisomes in the hepatocytes. These results indicate that DHEA-A, as well as clofibrate, may prevent OA-induced fatty liver." @default.
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- W2075003568 date "1998-01-01" @default.
- W2075003568 modified "2023-09-26" @default.
- W2075003568 title "Preventive Effects of Dehydroepiandrosterone Acetate on the Fatty Liver Induced by Orotic Acid in Male Rats." @default.
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- W2075003568 doi "https://doi.org/10.1538/expanim.47.257" @default.
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