FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075008368> ?p ?o ?g. }

• W2075008368 endingPage "1474" @default.
• W2075008368 startingPage "1469" @default.
• W2075008368 abstract "Pluripotent stem cells (PSC) are functionally characterized by their capacity to differentiate into all the cell types from the three germ layers. A wide range of markers, the expression of which is associated with pluripotency, has been used as surrogate evidence of PSC pluripotency, but their respective relevance is poorly documented. Here, we compared by polychromatic flow cytometry the kinetics of loss of expression of eight widely used pluripotency markers (SSEA3, SSEA4, TRA-1-60, TRA-1-81, CD24, OCT4, NANOG, and alkaline phosphatase [AP]) at days 0, 5, 7, and 9 after induction of PSC differentiation into cells representative of the three germ layers. Strikingly, each marker showed a different and specific kinetics of disappearance that was similar in all the PSC lines used and for all the induced differentiation pathways. OCT4, SSEA3, and TRA-1-60 were repeatedly the first markers to be downregulated, and their expression was completely lost at day 9. By contrast, AP activity, CD24, and NANOG proteins were still detectable at day 9. In addition, we show that differentiation markers are coexpressed with pluripotency markers before the latter begin to disappear. These results suggest that OCT4, SSEA3, and TRA-1-60 might be better to trace in vitro the emergence of pluripotent cells during reprogramming." @default.
• W2075008368 created "2016-06-24" @default.
• W2075008368 creator A5007988088 @default.
• W2075008368 creator A5025780107 @default.
• W2075008368 creator A5030135901 @default.
• W2075008368 creator A5047337533 @default.
• W2075008368 creator A5051212502 @default.
• W2075008368 creator A5051689782 @default.
• W2075008368 creator A5062891938 @default.
• W2075008368 creator A5065250369 @default.
• W2075008368 creator A5085684624 @default.
• W2075008368 date "2011-08-19" @default.
• W2075008368 modified "2023-10-13" @default.
• W2075008368 title "Brief Report: Benchmarking Human Pluripotent Stem Cell Markers During Differentiation Into the Three Germ Layers Unveils a Striking Heterogeneity: All Markers Are Not Equal" @default.
• W2075008368 cites W1968810092 @default.
• W2075008368 cites W1969202196 @default.
• W2075008368 cites W1981809048 @default.
• W2075008368 cites W1988865085 @default.
• W2075008368 cites W1995829644 @default.
• W2075008368 cites W2000927180 @default.
• W2075008368 cites W2004368167 @default.
• W2075008368 cites W2008995006 @default.
• W2075008368 cites W2011322953 @default.
• W2075008368 cites W2038404321 @default.
• W2075008368 cites W2041255419 @default.
• W2075008368 cites W2045440019 @default.
• W2075008368 cites W2065268746 @default.
• W2075008368 cites W2067161271 @default.
• W2075008368 cites W2073759231 @default.
• W2075008368 cites W2077613352 @default.
• W2075008368 cites W2084201375 @default.
• W2075008368 cites W2084913785 @default.
• W2075008368 cites W2086943348 @default.
• W2075008368 cites W2087786585 @default.
• W2075008368 cites W2088088839 @default.
• W2075008368 cites W2100021882 @default.
• W2075008368 cites W2113415712 @default.
• W2075008368 cites W2148108791 @default.
• W2075008368 doi "https://doi.org/10.1002/stem.681" @default.
• W2075008368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21714037" @default.
• W2075008368 hasPublicationYear "2011" @default.
• W2075008368 type Work @default.
• W2075008368 sameAs 2075008368 @default.
• W2075008368 citedByCount "36" @default.
• W2075008368 countsByYear W20750083682012 @default.
• W2075008368 countsByYear W20750083682013 @default.
• W2075008368 countsByYear W20750083682014 @default.
• W2075008368 countsByYear W20750083682015 @default.
• W2075008368 countsByYear W20750083682016 @default.
• W2075008368 countsByYear W20750083682017 @default.
• W2075008368 countsByYear W20750083682018 @default.
• W2075008368 countsByYear W20750083682019 @default.
• W2075008368 countsByYear W20750083682020 @default.
• W2075008368 countsByYear W20750083682021 @default.
• W2075008368 countsByYear W20750083682023 @default.
• W2075008368 crossrefType "journal-article" @default.
• W2075008368 hasAuthorship W2075008368A5007988088 @default.
• W2075008368 hasAuthorship W2075008368A5025780107 @default.
• W2075008368 hasAuthorship W2075008368A5030135901 @default.
• W2075008368 hasAuthorship W2075008368A5047337533 @default.
• W2075008368 hasAuthorship W2075008368A5051212502 @default.
• W2075008368 hasAuthorship W2075008368A5051689782 @default.
• W2075008368 hasAuthorship W2075008368A5062891938 @default.
• W2075008368 hasAuthorship W2075008368A5065250369 @default.
• W2075008368 hasAuthorship W2075008368A5085684624 @default.
• W2075008368 hasConcept C104317684 @default.
• W2075008368 hasConcept C107459253 @default.
• W2075008368 hasConcept C145103041 @default.
• W2075008368 hasConcept C148738053 @default.
• W2075008368 hasConcept C1491633281 @default.
• W2075008368 hasConcept C153911025 @default.
• W2075008368 hasConcept C18155467 @default.
• W2075008368 hasConcept C207168726 @default.
• W2075008368 hasConcept C207701140 @default.
• W2075008368 hasConcept C2777933648 @default.
• W2075008368 hasConcept C2778106681 @default.
• W2075008368 hasConcept C2778463287 @default.
• W2075008368 hasConcept C2780932548 @default.
• W2075008368 hasConcept C28328180 @default.
• W2075008368 hasConcept C54355233 @default.
• W2075008368 hasConcept C77255625 @default.
• W2075008368 hasConcept C86803240 @default.
• W2075008368 hasConcept C95444343 @default.
• W2075008368 hasConceptScore W2075008368C104317684 @default.
• W2075008368 hasConceptScore W2075008368C107459253 @default.
• W2075008368 hasConceptScore W2075008368C145103041 @default.
• W2075008368 hasConceptScore W2075008368C148738053 @default.
• W2075008368 hasConceptScore W2075008368C1491633281 @default.
• W2075008368 hasConceptScore W2075008368C153911025 @default.
• W2075008368 hasConceptScore W2075008368C18155467 @default.
• W2075008368 hasConceptScore W2075008368C207168726 @default.
• W2075008368 hasConceptScore W2075008368C207701140 @default.
• W2075008368 hasConceptScore W2075008368C2777933648 @default.
• W2075008368 hasConceptScore W2075008368C2778106681 @default.
• W2075008368 hasConceptScore W2075008368C2778463287 @default.
• W2075008368 hasConceptScore W2075008368C2780932548 @default.
• W2075008368 hasConceptScore W2075008368C28328180 @default.
• W2075008368 hasConceptScore W2075008368C54355233 @default.

• next