Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075023944> ?p ?o ?g. }
- W2075023944 endingPage "4337" @default.
- W2075023944 startingPage "4326" @default.
- W2075023944 abstract "When fed high-fat diets, male LDLR−/− mice develop obesity, hyperlipidemia, hyperglycemia, and arteriosclerotic calcification. An osteogenic Msx-Wnt regulatory program is concomitantly upregulated in the vasculature. To better understand the mechanisms of diabetic arteriosclerosis, we generated SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR−/− mice, assessing the impact of Msx1+Msx2 gene deletion in vascular myofibroblast and smooth muscle cells. Aortic Msx2 and Msx1 were decreased by 95% and 34% in SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR−/− animals versus Msx1(fl/fl);Msx2(fl/fl);LDLR−/− controls, respectively. Aortic calcium was reduced by 31%, and pulse wave velocity, an index of stiffness, was decreased in SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR−/− mice vs. controls. Fasting blood glucose and lipids did not differ, yet SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR−/− siblings became more obese. Aortic adventitial myofibroblasts from SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR−/− mice exhibited reduced osteogenic gene expression and mineralizing potential with concomitant reduction in multiple Wnt genes. Sonic hedgehog (Shh) and Sca1, markers of aortic osteogenic progenitors, were also reduced, paralleling a 78% reduction in alkaline phosphatase (TNAP)–positive adventitial myofibroblasts. RNA interference revealed that although Msx1+Msx2 supports TNAP and Wnt7b expression, Msx1 selectively maintains Shh and Msx2 sustains Wnt2, Wnt5a, and Sca1 expression in aortic adventitial myofibroblast cultures. Thus, Msx1 and Msx2 support vascular mineralization by directing the osteogenic programming of aortic progenitors in diabetic arteriosclerosis." @default.
- W2075023944 created "2016-06-24" @default.
- W2075023944 creator A5007118272 @default.
- W2075023944 creator A5012163023 @default.
- W2075023944 creator A5020860852 @default.
- W2075023944 creator A5021257919 @default.
- W2075023944 creator A5022208062 @default.
- W2075023944 creator A5034442930 @default.
- W2075023944 creator A5042214986 @default.
- W2075023944 creator A5072836026 @default.
- W2075023944 creator A5079552215 @default.
- W2075023944 creator A5090693552 @default.
- W2075023944 date "2014-11-13" @default.
- W2075023944 modified "2023-10-17" @default.
- W2075023944 title "Targeted Reduction of Vascular <i>Msx1</i> and <i>Msx2</i> Mitigates Arteriosclerotic Calcification and Aortic Stiffness in <i>LDLR</i>-Deficient Mice Fed Diabetogenic Diets" @default.
- W2075023944 cites W1536067283 @default.
- W2075023944 cites W1541819796 @default.
- W2075023944 cites W1968858235 @default.
- W2075023944 cites W1970882491 @default.
- W2075023944 cites W1971955679 @default.
- W2075023944 cites W1972600391 @default.
- W2075023944 cites W1985012226 @default.
- W2075023944 cites W1985945376 @default.
- W2075023944 cites W1991593795 @default.
- W2075023944 cites W1994867142 @default.
- W2075023944 cites W2000279901 @default.
- W2075023944 cites W2006174445 @default.
- W2075023944 cites W2010221831 @default.
- W2075023944 cites W2012334457 @default.
- W2075023944 cites W2016736317 @default.
- W2075023944 cites W2017593144 @default.
- W2075023944 cites W2022853418 @default.
- W2075023944 cites W2029187758 @default.
- W2075023944 cites W2038701567 @default.
- W2075023944 cites W2039728399 @default.
- W2075023944 cites W2046854220 @default.
- W2075023944 cites W2049806614 @default.
- W2075023944 cites W2051580972 @default.
- W2075023944 cites W2082082688 @default.
- W2075023944 cites W2091371315 @default.
- W2075023944 cites W2099101745 @default.
- W2075023944 cites W2100039503 @default.
- W2075023944 cites W2102106885 @default.
- W2075023944 cites W2102161788 @default.
- W2075023944 cites W2103680698 @default.
- W2075023944 cites W2108409970 @default.
- W2075023944 cites W2118807251 @default.
- W2075023944 cites W2121809636 @default.
- W2075023944 cites W2121860616 @default.
- W2075023944 cites W2123591590 @default.
- W2075023944 cites W2123740493 @default.
- W2075023944 cites W2132983925 @default.
- W2075023944 cites W2133706890 @default.
- W2075023944 cites W2135192839 @default.
- W2075023944 cites W2135760784 @default.
- W2075023944 cites W2139261233 @default.
- W2075023944 cites W2144284875 @default.
- W2075023944 cites W2147783647 @default.
- W2075023944 cites W2148626940 @default.
- W2075023944 cites W2155756637 @default.
- W2075023944 cites W2156227990 @default.
- W2075023944 cites W2157439044 @default.
- W2075023944 cites W2168521667 @default.
- W2075023944 cites W2171062983 @default.
- W2075023944 doi "https://doi.org/10.2337/db14-0326" @default.
- W2075023944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4237989" @default.
- W2075023944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25056439" @default.
- W2075023944 hasPublicationYear "2014" @default.
- W2075023944 type Work @default.
- W2075023944 sameAs 2075023944 @default.
- W2075023944 citedByCount "64" @default.
- W2075023944 countsByYear W20750239442015 @default.
- W2075023944 countsByYear W20750239442016 @default.
- W2075023944 countsByYear W20750239442017 @default.
- W2075023944 countsByYear W20750239442018 @default.
- W2075023944 countsByYear W20750239442019 @default.
- W2075023944 countsByYear W20750239442020 @default.
- W2075023944 countsByYear W20750239442021 @default.
- W2075023944 countsByYear W20750239442022 @default.
- W2075023944 countsByYear W20750239442023 @default.
- W2075023944 crossrefType "journal-article" @default.
- W2075023944 hasAuthorship W2075023944A5007118272 @default.
- W2075023944 hasAuthorship W2075023944A5012163023 @default.
- W2075023944 hasAuthorship W2075023944A5020860852 @default.
- W2075023944 hasAuthorship W2075023944A5021257919 @default.
- W2075023944 hasAuthorship W2075023944A5022208062 @default.
- W2075023944 hasAuthorship W2075023944A5034442930 @default.
- W2075023944 hasAuthorship W2075023944A5042214986 @default.
- W2075023944 hasAuthorship W2075023944A5072836026 @default.
- W2075023944 hasAuthorship W2075023944A5079552215 @default.
- W2075023944 hasAuthorship W2075023944A5090693552 @default.
- W2075023944 hasBestOaLocation W20750239441 @default.
- W2075023944 hasConcept C126322002 @default.
- W2075023944 hasConcept C134018914 @default.
- W2075023944 hasConcept C2776393769 @default.
- W2075023944 hasConcept C2778163477 @default.
- W2075023944 hasConcept C2779980429 @default.
- W2075023944 hasConcept C2780072125 @default.