FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075036701> ?p ?o ?g. }

• W2075036701 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCThe development of new therapeutic agents has dramatically improved the quality of life and survival rate of patients suffering from a variety of disorders. However, drug delivery innovations are required to further improve the success rate of these treatments because approximately 40% of the newly discovered, promising small molecule therapeutics have poor aqueous solubility and cannot be delivered systemically. Rationally-designed, nanoscopic drug carriers offer a promising approach to achieving these goals due to their inherent ability to overcome multiple biological barriers. Ideally, a drug delivery system will not only be stable to systemic administration, but also be versatile enough to encapsulate a diverse range of molecules leading to decreased developmental and regulatory hurdles. These goals were the driving force behind the development of Intezyne's IVECT™ Method, which is based on tri-block copolymer micelle technology; spherical nano-sized drug carriers formed by the assembly of amphiphilic block copolymers in water. This modular drug delivery platform can be tailored to accommodate a wide range of drugs, biologics or diagnostics, improve post-administration stability, vary the micelle size, control the release of the therapeutic, and target specific diseased cells based on active targeting strategies. The purpose of this study is to demonstrate encapsulation of a variety of chemotherapeutics utilizing one polymer system, and show that crosslinked micelles have improved pharmacokinetic and toxicology profiles compared to the free drugs in animal models. To this end, formulations of gemcitabine, paclitaxel, doxorubicin and SN-38 were prepared and characterized for nanoparticle size distribution by DLS and active drug weight loading by HPLC. All micelles were 30-80 nm in size with weight loadings of between 2 and 10 %. PK data from cannulated rats demonstrated significant improvement in the CMax and AUC for encapsulated crosslinked formulations, compared to the free drugs. Toxicity profiling in CD-1 mice demonstrated that the polymer alone was very safe, as an MTD was not reachable, and that the crosslinked encapsulated formulations were tolerated at significantly higher doses compared to the free drugs. In conclusion, we have demonstrated that Intezyne's IVECT™ Method is extremely versatile and results in significant improvements in the overall pharmacology of chemotherapeutics.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5489." @default.
• W2075036701 created "2016-06-24" @default.
• W2075036701 creator A5007263291 @default.
• W2075036701 creator A5019761569 @default.
• W2075036701 creator A5041619584 @default.
• W2075036701 creator A5087620519 @default.
• W2075036701 date "2010-04-15" @default.
• W2075036701 modified "2023-09-27" @default.
• W2075036701 title "Abstract 5489: The IVECT™ method, a versatile micelle for the delivery of chemotherapeutic drugs" @default.
• W2075036701 doi "https://doi.org/10.1158/1538-7445.am10-5489" @default.
• W2075036701 hasPublicationYear "2010" @default.
• W2075036701 type Work @default.
• W2075036701 sameAs 2075036701 @default.
• W2075036701 citedByCount "0" @default.
• W2075036701 crossrefType "proceedings-article" @default.
• W2075036701 hasAuthorship W2075036701A5007263291 @default.
• W2075036701 hasAuthorship W2075036701A5019761569 @default.
• W2075036701 hasAuthorship W2075036701A5041619584 @default.
• W2075036701 hasAuthorship W2075036701A5087620519 @default.
• W2075036701 hasConcept C11268172 @default.
• W2075036701 hasConcept C121608353 @default.
• W2075036701 hasConcept C126322002 @default.
• W2075036701 hasConcept C13245373 @default.
• W2075036701 hasConcept C147789679 @default.
• W2075036701 hasConcept C171250308 @default.
• W2075036701 hasConcept C184651966 @default.
• W2075036701 hasConcept C185592680 @default.
• W2075036701 hasConcept C192562407 @default.
• W2075036701 hasConcept C2777292972 @default.
• W2075036701 hasConcept C2779820397 @default.
• W2075036701 hasConcept C2780035454 @default.
• W2075036701 hasConcept C71924100 @default.
• W2075036701 hasConcept C98274493 @default.
• W2075036701 hasConceptScore W2075036701C11268172 @default.
• W2075036701 hasConceptScore W2075036701C121608353 @default.
• W2075036701 hasConceptScore W2075036701C126322002 @default.
• W2075036701 hasConceptScore W2075036701C13245373 @default.
• W2075036701 hasConceptScore W2075036701C147789679 @default.
• W2075036701 hasConceptScore W2075036701C171250308 @default.
• W2075036701 hasConceptScore W2075036701C184651966 @default.
• W2075036701 hasConceptScore W2075036701C185592680 @default.
• W2075036701 hasConceptScore W2075036701C192562407 @default.
• W2075036701 hasConceptScore W2075036701C2777292972 @default.
• W2075036701 hasConceptScore W2075036701C2779820397 @default.
• W2075036701 hasConceptScore W2075036701C2780035454 @default.
• W2075036701 hasConceptScore W2075036701C71924100 @default.
• W2075036701 hasConceptScore W2075036701C98274493 @default.
• W2075036701 hasLocation W20750367011 @default.
• W2075036701 hasOpenAccess W2075036701 @default.
• W2075036701 hasPrimaryLocation W20750367011 @default.
• W2075036701 hasRelatedWork W1501292984 @default.
• W2075036701 hasRelatedWork W1804398254 @default.
• W2075036701 hasRelatedWork W1978271981 @default.
• W2075036701 hasRelatedWork W2060715850 @default.
• W2075036701 hasRelatedWork W2081833688 @default.
• W2075036701 hasRelatedWork W2081911649 @default.
• W2075036701 hasRelatedWork W2113768515 @default.
• W2075036701 hasRelatedWork W2136812760 @default.
• W2075036701 hasRelatedWork W2366562245 @default.
• W2075036701 hasRelatedWork W2751366318 @default.
• W2075036701 hasRelatedWork W2755706916 @default.
• W2075036701 hasRelatedWork W2917679289 @default.
• W2075036701 hasRelatedWork W2966612446 @default.
• W2075036701 hasRelatedWork W3000714215 @default.
• W2075036701 hasRelatedWork W3043039016 @default.
• W2075036701 hasRelatedWork W3087253880 @default.
• W2075036701 hasRelatedWork W3090166601 @default.
• W2075036701 hasRelatedWork W3168541521 @default.
• W2075036701 hasRelatedWork W3171435783 @default.
• W2075036701 hasRelatedWork W3185941402 @default.
• W2075036701 isParatext "false" @default.
• W2075036701 isRetracted "false" @default.
• W2075036701 magId "2075036701" @default.
• W2075036701 workType "article" @default.