FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075044939> ?p ?o ?g. }

• W2075044939 endingPage "170" @default.
• W2075044939 startingPage "161" @default.
• W2075044939 abstract "Mesenchymal stem cells (MSC) promote functional recovery in experimental models of central nervous system (CNS) pathology and are currently being tested in clinical trials for stroke, multiple sclerosis and CNS injury. Their beneficial effects are attributed to the activation of endogenous CNS protection and repair processes as well as immune regulation but their mechanisms of action are poorly understood. Here we investigated the neuroprotective effects of mouse MSC in rodent MSC-neuron co-cultures and mice using models of glutamate excitotoxicity. A 24h pre-culture of mouse primary cortical neurons with MSC protected them against glutamate (NMDA) receptor-induced death and conditioned medium from MSC (MSC CM) was sufficient for this effect. Protection by MSC CM was associated with reduced mRNA levels of genes encoding NMDA receptor subunits, and increased levels for genes associated with non-neuronal and stem cell types, as shown by RT-PCR and cDNA microarray analyses. Changes in gene expression were not associated with alterations in cell lineage representation within the cultures. Further, MSC CM-mediated neuroprotection in rat retinal ganglion cells was associated with reduced glutamate-induced calcium influx. The adoptive transfer of EGFP(+)MSC in a mouse kainic acid epilepsy model also provided neuroprotection against glutamate excitotoxicity in vivo, as shown by reduced neuron damage and glial cell activation in the hippocampus. These results show that MSC mediate direct neuroprotection by reducing neuronal sensitivity to glutamate receptor ligands and altering gene expression, and suggest a link between the therapeutic effects of MSC and the activation of cell plasticity in the damaged CNS." @default.
• W2075044939 created "2016-06-24" @default.
• W2075044939 creator A5000053790 @default.
• W2075044939 creator A5010946173 @default.
• W2075044939 creator A5054441391 @default.
• W2075044939 creator A5059148636 @default.
• W2075044939 creator A5063645480 @default.
• W2075044939 creator A5069746882 @default.
• W2075044939 creator A5070399372 @default.
• W2075044939 creator A5071797333 @default.
• W2075044939 creator A5087643606 @default.
• W2075044939 creator A5090673162 @default.
• W2075044939 date "2012-07-01" @default.
• W2075044939 modified "2023-09-27" @default.
• W2075044939 title "Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function" @default.
• W2075044939 cites W1530284699 @default.
• W2075044939 cites W1534322556 @default.
• W2075044939 cites W1550049909 @default.
• W2075044939 cites W1597802523 @default.
• W2075044939 cites W1824170643 @default.
• W2075044939 cites W1973987134 @default.
• W2075044939 cites W1976968085 @default.
• W2075044939 cites W1979043688 @default.
• W2075044939 cites W1979635499 @default.
• W2075044939 cites W1982098988 @default.
• W2075044939 cites W1982198467 @default.
• W2075044939 cites W2000266670 @default.
• W2075044939 cites W2000944968 @default.
• W2075044939 cites W2001627351 @default.
• W2075044939 cites W2001908895 @default.
• W2075044939 cites W2005848913 @default.
• W2075044939 cites W2012549032 @default.
• W2075044939 cites W2012658246 @default.
• W2075044939 cites W2013327644 @default.
• W2075044939 cites W2013869536 @default.
• W2075044939 cites W2016472046 @default.
• W2075044939 cites W2019270281 @default.
• W2075044939 cites W2030412297 @default.
• W2075044939 cites W2035098555 @default.
• W2075044939 cites W2036452348 @default.
• W2075044939 cites W2038881167 @default.
• W2075044939 cites W2039668337 @default.
• W2075044939 cites W2040033061 @default.
• W2075044939 cites W2040622617 @default.
• W2075044939 cites W2044806819 @default.
• W2075044939 cites W2044858838 @default.
• W2075044939 cites W2046091508 @default.
• W2075044939 cites W2048052588 @default.
• W2075044939 cites W2059066863 @default.
• W2075044939 cites W2061514685 @default.
• W2075044939 cites W2066145942 @default.
• W2075044939 cites W2066456818 @default.
• W2075044939 cites W2068969996 @default.
• W2075044939 cites W2069527370 @default.
• W2075044939 cites W2073939513 @default.
• W2075044939 cites W2076600727 @default.
• W2075044939 cites W2082879602 @default.
• W2075044939 cites W2091187766 @default.
• W2075044939 cites W2093518077 @default.
• W2075044939 cites W2094635970 @default.
• W2075044939 cites W2097087118 @default.
• W2075044939 cites W2105765874 @default.
• W2075044939 cites W2106117542 @default.
• W2075044939 cites W2109807917 @default.
• W2075044939 cites W2115444861 @default.
• W2075044939 cites W2118969721 @default.
• W2075044939 cites W2119376007 @default.
• W2075044939 cites W2127097320 @default.
• W2075044939 cites W2131950918 @default.
• W2075044939 cites W2133230064 @default.
• W2075044939 cites W2142594288 @default.
• W2075044939 cites W2145817021 @default.
• W2075044939 cites W2148841089 @default.
• W2075044939 cites W2149766411 @default.
• W2075044939 cites W2155945484 @default.
• W2075044939 cites W2158590037 @default.
• W2075044939 cites W2168436056 @default.
• W2075044939 cites W2302704746 @default.
• W2075044939 cites W4253992140 @default.
• W2075044939 cites W89399424 @default.
• W2075044939 doi "https://doi.org/10.1016/j.expneurol.2012.04.011" @default.
• W2075044939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22561409" @default.
• W2075044939 hasPublicationYear "2012" @default.
• W2075044939 type Work @default.
• W2075044939 sameAs 2075044939 @default.
• W2075044939 citedByCount "83" @default.
• W2075044939 countsByYear W20750449392012 @default.
• W2075044939 countsByYear W20750449392013 @default.
• W2075044939 countsByYear W20750449392014 @default.
• W2075044939 countsByYear W20750449392015 @default.
• W2075044939 countsByYear W20750449392016 @default.
• W2075044939 countsByYear W20750449392017 @default.
• W2075044939 countsByYear W20750449392018 @default.
• W2075044939 countsByYear W20750449392019 @default.
• W2075044939 countsByYear W20750449392020 @default.
• W2075044939 countsByYear W20750449392021 @default.
• W2075044939 countsByYear W20750449392022 @default.
• W2075044939 countsByYear W20750449392023 @default.

• next