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- W2075047155 abstract "A sialoglycan containing 8.2% galactosamine, 6.7% glucosamine, 15% neutral sugar, 12% sialic acid and 25% protein was isolated from the interphotoreceptor matrix of the retina. On mild acid hydrolysis, the two sugars initially released were sialic acid and fucose; it was deduced that these monosaccharides occupy terminal positions in the molecule. Further studies showed that native sialoglycan could not be degraded by glycosidic enzymes; only after removal of the terminal sialic acid residues was it susceptible to attack. The results of selective degradation of the desialized sialoglycan with crude glycosidases suggest that in the intact molecule, galactose occupies a subterminal position. The amino sugars appear to the most internally located components. The protein moiety of the the sialoglycan is joined by alkali-labile O-glycosidic bonds through serine and threonine to a carbohydrate residue, possibly galactosamine. A chondroitin sulfate preparation isolated from retina contained 30.7% uronic acid, 23.6% galactosamine, 5.5.% neutral sugar, 1.2% sulfate and 8.2 protein. Treatment with 0.5 M NaOH resulted in the destruction of 51% of the serine and 30% of the threonine, indicating that the peptide portion is linked through O-glycosidic bonds to a carbohydrate residue. Xylose and galactose were the only neutral sugars detected in the chondroitin sulfate. From the molar ratios of galactosamine to xylose and of galactosamine to hydroxy amino acid destroyed by β-carbonyl elimination, it was calculated that the chondroitin sulfate contained 19–22 disaccharide units/chain. For a low sulfated chondroitin sulfate, this would correspond to a number-average molecular weight of 8200–9500. The molecular weight determined from ultracentrifuge data was 9200. It was conluded that the proteoglycan isolated from the retina consisted of a single chondroitin sulfate-peptide chain, of shorter and hence of lower molecular weight, than those found in other tissues." @default.
- W2075047155 created "2016-06-24" @default.
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- W2075047155 date "1971-12-21" @default.
- W2075047155 modified "2023-10-18" @default.
- W2075047155 title "Amino sugar-containing compounds of the retina II. Structural studies" @default.
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- W2075047155 doi "https://doi.org/10.1016/0304-4165(71)90149-8" @default.
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