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• W2075047941 abstract "The identification of small molecule modulators of biological processes mediated via protein-protein interactions has generally proved to be a challenging endeavor. In the case of the thrombopoietin receptor (TPOr), however, a number of small molecule types have been reported to display biological activity similar to that of the agonist protein TPO. Through a detailed analysis of structure-activity relationships, X-ray crystal structures, NMR coupling constants, nuclear Overhauser effects, and computational data, we have determined the agonism-inducing conformation of one series of small molecule TPOr agonists. The relationship of this agonism-inducing conformation to that of other series of TPO receptor agonists is discussed." @default.
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• W2075047941 date "2008-05-01" @default.
• W2075047941 modified "2023-09-27" @default.
• W2075047941 title "Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists" @default.
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• W2075047941 doi "https://doi.org/10.1016/j.bmcl.2008.03.052" @default.
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