FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075058988> ?p ?o ?g. }

• W2075058988 endingPage "778" @default.
• W2075058988 startingPage "773" @default.
• W2075058988 abstract "Differential alterations of the spliceosomal Uridylic acid rich small nuclear RNAs (UsnRNAs) (U1, U2, U4, U5, and U6) are reported to be associated with cellular proliferation and development, but definitive information is scarce and also elusive. An attempt is made in this study to analyze the metabolic patterns of major spliceosomal UsnRNAs, during tumor development, in an in vitro carcinogenesis model of 20-methylcholanthrene (MCA)-transformed Swiss Mouse Embryonic Fibroblast (MEF), designated as CNCI-PM-20. MEF cells, after treatment with 20-MCA, progressed through a sequence of passages with distinct and heritable changes, finally becoming neoplastic at passage-42 (P42). A differential expression pattern of major UsnRNAs was observed during this process. The abundance of U1 was 20% below control (P1) at passage-20 (P20), followed by a gradual increase up until P42 (∼12% above the P1 value). The abundance of U2 was more or less constant during the cellular transformation. U4 showed a trend of increase, with above 30% abundance than control at P20, followed by a significant increase at P36 and P42 (1.5- and 2-fold, respectively, P-value <0.01). U5 also followed an identical pattern, with an increase of 70% compared to control (P-value <0.05) at P42. Interestingly, U6 gradually decreased from P20 onwards up until P42, with 22% at P20 and 67% at P42 (P-value <0.01). An overall significant quantitative alteration in abundance of U4, U5, and U6, observed in our study, contributes to the understanding of the fact that, the metabolism of major spliceosomal UsnRNAs is differentially regulated during the process of neoplastic transformation. Mol. Carcinog. © 2009 Wiley-Liss, Inc." @default.
• W2075058988 created "2016-06-24" @default.
• W2075058988 creator A5010072523 @default.
• W2075058988 creator A5017297560 @default.
• W2075058988 creator A5050183636 @default.
• W2075058988 creator A5052643113 @default.
• W2075058988 date "2009-06-03" @default.
• W2075058988 modified "2023-09-26" @default.
• W2075058988 title "Differential alterations in metabolic pattern of the spliceosomal uridylic acid-rich small nuclear RNAs (UsnRNAs) during malignant transformation of 20-methylcholanthrene-induced mouse CNCI-PM-20 embryonic fibroblasts" @default.
• W2075058988 cites W104683999 @default.
• W2075058988 cites W1496350633 @default.
• W2075058988 cites W1515283239 @default.
• W2075058988 cites W1607233960 @default.
• W2075058988 cites W1859397449 @default.
• W2075058988 cites W1908800320 @default.
• W2075058988 cites W1968546049 @default.
• W2075058988 cites W1969206787 @default.
• W2075058988 cites W1971314065 @default.
• W2075058988 cites W1974896413 @default.
• W2075058988 cites W1977291032 @default.
• W2075058988 cites W1983249032 @default.
• W2075058988 cites W1985991078 @default.
• W2075058988 cites W1987109078 @default.
• W2075058988 cites W1995272144 @default.
• W2075058988 cites W1995324078 @default.
• W2075058988 cites W1997290172 @default.
• W2075058988 cites W2000713154 @default.
• W2075058988 cites W2026368332 @default.
• W2075058988 cites W2027851393 @default.
• W2075058988 cites W2032000078 @default.
• W2075058988 cites W2034597477 @default.
• W2075058988 cites W2036746094 @default.
• W2075058988 cites W2039009543 @default.
• W2075058988 cites W2039950235 @default.
• W2075058988 cites W2071869698 @default.
• W2075058988 cites W2079578031 @default.
• W2075058988 cites W2083597283 @default.
• W2075058988 cites W2096575861 @default.
• W2075058988 cites W2110830834 @default.
• W2075058988 cites W2119729366 @default.
• W2075058988 cites W2126456725 @default.
• W2075058988 cites W2127235801 @default.
• W2075058988 cites W2134388771 @default.
• W2075058988 cites W2140023753 @default.
• W2075058988 cites W2147990611 @default.
• W2075058988 cites W2150886151 @default.
• W2075058988 cites W2151499541 @default.
• W2075058988 cites W2155915345 @default.
• W2075058988 cites W2164355184 @default.
• W2075058988 cites W2165268483 @default.
• W2075058988 cites W2169957938 @default.
• W2075058988 cites W2175319115 @default.
• W2075058988 cites W2229805112 @default.
• W2075058988 cites W2284533367 @default.
• W2075058988 cites W4213004729 @default.
• W2075058988 doi "https://doi.org/10.1002/mc.20556" @default.
• W2075058988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19496104" @default.
• W2075058988 hasPublicationYear "2009" @default.
• W2075058988 type Work @default.
• W2075058988 sameAs 2075058988 @default.
• W2075058988 citedByCount "2" @default.
• W2075058988 countsByYear W20750589882019 @default.
• W2075058988 countsByYear W20750589882020 @default.
• W2075058988 crossrefType "journal-article" @default.
• W2075058988 hasAuthorship W2075058988A5010072523 @default.
• W2075058988 hasAuthorship W2075058988A5017297560 @default.
• W2075058988 hasAuthorship W2075058988A5050183636 @default.
• W2075058988 hasAuthorship W2075058988A5052643113 @default.
• W2075058988 hasConcept C114246631 @default.
• W2075058988 hasConcept C121608353 @default.
• W2075058988 hasConcept C153911025 @default.
• W2075058988 hasConcept C202751555 @default.
• W2075058988 hasConcept C2780303067 @default.
• W2075058988 hasConcept C2780381497 @default.
• W2075058988 hasConcept C54355233 @default.
• W2075058988 hasConcept C555283112 @default.
• W2075058988 hasConcept C86803240 @default.
• W2075058988 hasConcept C95444343 @default.
• W2075058988 hasConceptScore W2075058988C114246631 @default.
• W2075058988 hasConceptScore W2075058988C121608353 @default.
• W2075058988 hasConceptScore W2075058988C153911025 @default.
• W2075058988 hasConceptScore W2075058988C202751555 @default.
• W2075058988 hasConceptScore W2075058988C2780303067 @default.
• W2075058988 hasConceptScore W2075058988C2780381497 @default.
• W2075058988 hasConceptScore W2075058988C54355233 @default.
• W2075058988 hasConceptScore W2075058988C555283112 @default.
• W2075058988 hasConceptScore W2075058988C86803240 @default.
• W2075058988 hasConceptScore W2075058988C95444343 @default.
• W2075058988 hasIssue "9" @default.
• W2075058988 hasLocation W20750589881 @default.
• W2075058988 hasLocation W20750589882 @default.
• W2075058988 hasOpenAccess W2075058988 @default.
• W2075058988 hasPrimaryLocation W20750589881 @default.
• W2075058988 hasRelatedWork W1553017993 @default.
• W2075058988 hasRelatedWork W1586356984 @default.
• W2075058988 hasRelatedWork W1981389223 @default.
• W2075058988 hasRelatedWork W1982137790 @default.
• W2075058988 hasRelatedWork W2033530968 @default.

• next