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• W2075070056 abstract "Optimisation of a series of 5-(heterocyclyl)tryptamines led to the identification of the symmetrically substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT1D receptor affinity and selectivity. The triazole (8) is the most potent and selective, orally bioavailable, 5-HT1D receptor agonist identified to date, showing an order of magnitude greater potency than the clinical compound sumatriptan with improved subtype selectivity." @default.
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• W2075070056 date "1996-08-01" @default.
• W2075070056 modified "2023-10-11" @default.
• W2075070056 title "The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogues: Potent and selective agonists for 5-HT1D receptors" @default.
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• W2075070056 doi "https://doi.org/10.1016/0960-894x(96)00324-1" @default.
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