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• W2075081362 abstract "Isoprostane E(2) (8-iso-PGE) and F(2alpha) (8-iso-PGF) sensitize nociceptors and capsaicin-sensitive DRG neurons. In this study we investigated the cyclooxygenase-dependence of isoprostane-induced C-nociceptor sensitization. Systemic pretreatment of rats with ketorolac (1 and 10 mg/kg) abolished 8-iso-PGF sensitization and reduced the effects of 8-iso-PGE. Ibuprofen (30 mg/kg) blocked all sensitizing effects. These data suggest that some algesic properties of isoprostanes are mediated via prostanoid synthesis." @default.
• W2075081362 created "2016-06-24" @default.
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• W2075081362 date "2000-06-01" @default.
• W2075081362 modified "2023-09-28" @default.
• W2075081362 title "C-Nociceptor sensitization by isoprostanes is cyclooxygenase dependent" @default.
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• W2075081362 doi "https://doi.org/10.1016/s0006-8993(00)02306-4" @default.
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