FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075091661> ?p ?o ?g. }

• W2075091661 endingPage "G1324" @default.
• W2075091661 startingPage "G1315" @default.
• W2075091661 abstract "Members of the interleukin (IL)-12 family constitute subunits of IL-12, -23, and -27. These ILs represent pivotal mediators in the regulation of cell-mediated immune responses and in animal models of human inflammatory bowel disease. Recent work has suggested that intestinal endothelial cells might serve as a second line of defense in bacterial sensing of invading pathogens. The purpose of this study was to examine the production of IL-12 family members in intestinal endothelial cells (HIMEC). HIMEC were stimulated with proinflammatory agents (TNF-alpha, IFN-gamma, IL-1beta) and microbial antigens [LPS, lipoteichoic acid, peptidoglycan, CpG-DNA, flagellin, poly(I:C)]. Expression of IL-12 family members and of Toll-like receptor (TLR)3 in HIMEC was assessed by real-time RT-PCR, immunostaining, flow cytometry, and immunoblot analysis. HIMEC display an induction of Epstein-Barr virus-induced gene 3 (EBI3), IL-12p35, and IL-23p19, whereas no expression of IL-12p40 and IL-27p28 was detectable. The strongest induction was induced by proinflammatory factors known to utilize the NF-kappaB pathway, and expression of EBI3 and IL-23p19 was diminished by an NF-kappaB inhibitor. HIMEC display regulated expression of TLR3. Adhesion and transmigration assays showed proinflammatory responses after HIMEC stimulation. HIMEC are capable of producing IL-12 family members as a response to microbial stimuli. The TLR3 agonist, poly(I:C), was shown to enhance leukocyte adhesion in vitro in HIMEC. Our data suggest that the intestinal microvasculature is responsive to ligands of TLR3 expressed on intestinal endothelial cells, thereby adding to the regulation of adaptive immunity and leukocyte recruitment." @default.
• W2075091661 created "2016-06-24" @default.
• W2075091661 creator A5028859025 @default.
• W2075091661 creator A5033555498 @default.
• W2075091661 creator A5040792169 @default.
• W2075091661 creator A5069460640 @default.
• W2075091661 creator A5079947206 @default.
• W2075091661 creator A5086415630 @default.
• W2075091661 creator A5086461845 @default.
• W2075091661 creator A5091241342 @default.
• W2075091661 date "2007-12-01" @default.
• W2075091661 modified "2023-09-27" @default.
• W2075091661 title "Expression of IL-12-related molecules in human intestinal microvascular endothelial cells is regulated by TLR3" @default.
• W2075091661 cites W1480238487 @default.
• W2075091661 cites W1481735951 @default.
• W2075091661 cites W1488600638 @default.
• W2075091661 cites W1512595753 @default.
• W2075091661 cites W1566718798 @default.
• W2075091661 cites W1964909764 @default.
• W2075091661 cites W1967828047 @default.
• W2075091661 cites W1972101436 @default.
• W2075091661 cites W1972926790 @default.
• W2075091661 cites W1980668544 @default.
• W2075091661 cites W1981714996 @default.
• W2075091661 cites W1984107869 @default.
• W2075091661 cites W2000287523 @default.
• W2075091661 cites W2009101924 @default.
• W2075091661 cites W2009913617 @default.
• W2075091661 cites W2012466772 @default.
• W2075091661 cites W2016956768 @default.
• W2075091661 cites W2022200555 @default.
• W2075091661 cites W2022669535 @default.
• W2075091661 cites W2048267618 @default.
• W2075091661 cites W2052907030 @default.
• W2075091661 cites W2057505571 @default.
• W2075091661 cites W2065307318 @default.
• W2075091661 cites W2065575295 @default.
• W2075091661 cites W2087381596 @default.
• W2075091661 cites W2087905758 @default.
• W2075091661 cites W2093560642 @default.
• W2075091661 cites W2093949724 @default.
• W2075091661 cites W2096212737 @default.
• W2075091661 cites W2097762449 @default.
• W2075091661 cites W2099456939 @default.
• W2075091661 cites W2100649505 @default.
• W2075091661 cites W2104589433 @default.
• W2075091661 cites W2116113986 @default.
• W2075091661 cites W2123711491 @default.
• W2075091661 cites W2123786729 @default.
• W2075091661 cites W2146987449 @default.
• W2075091661 cites W2156877836 @default.
• W2075091661 cites W2159980792 @default.
• W2075091661 cites W2171463669 @default.
• W2075091661 cites W4238322028 @default.
• W2075091661 cites W4238394506 @default.
• W2075091661 doi "https://doi.org/10.1152/ajpgi.00142.2007" @default.
• W2075091661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17947455" @default.
• W2075091661 hasPublicationYear "2007" @default.
• W2075091661 type Work @default.
• W2075091661 sameAs 2075091661 @default.
• W2075091661 citedByCount "21" @default.
• W2075091661 countsByYear W20750916612012 @default.
• W2075091661 countsByYear W20750916612014 @default.
• W2075091661 countsByYear W20750916612015 @default.
• W2075091661 countsByYear W20750916612016 @default.
• W2075091661 countsByYear W20750916612020 @default.
• W2075091661 countsByYear W20750916612021 @default.
• W2075091661 countsByYear W20750916612022 @default.
• W2075091661 countsByYear W20750916612023 @default.
• W2075091661 crossrefType "journal-article" @default.
• W2075091661 hasAuthorship W2075091661A5028859025 @default.
• W2075091661 hasAuthorship W2075091661A5033555498 @default.
• W2075091661 hasAuthorship W2075091661A5040792169 @default.
• W2075091661 hasAuthorship W2075091661A5069460640 @default.
• W2075091661 hasAuthorship W2075091661A5079947206 @default.
• W2075091661 hasAuthorship W2075091661A5086415630 @default.
• W2075091661 hasAuthorship W2075091661A5086461845 @default.
• W2075091661 hasAuthorship W2075091661A5091241342 @default.
• W2075091661 hasConcept C13373296 @default.
• W2075091661 hasConcept C136449434 @default.
• W2075091661 hasConcept C153911025 @default.
• W2075091661 hasConcept C164027704 @default.
• W2075091661 hasConcept C170493617 @default.
• W2075091661 hasConcept C203014093 @default.
• W2075091661 hasConcept C2776709828 @default.
• W2075091661 hasConcept C2776914184 @default.
• W2075091661 hasConcept C2777338127 @default.
• W2075091661 hasConcept C2778420691 @default.
• W2075091661 hasConcept C2779489039 @default.
• W2075091661 hasConcept C38117629 @default.
• W2075091661 hasConcept C523546767 @default.
• W2075091661 hasConcept C54355233 @default.
• W2075091661 hasConcept C55493867 @default.
• W2075091661 hasConcept C68324877 @default.
• W2075091661 hasConcept C6977687 @default.
• W2075091661 hasConcept C86803240 @default.
• W2075091661 hasConcept C8891405 @default.
• W2075091661 hasConcept C95444343 @default.

• next