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• W2075099242 endingPage "4332" @default.
• W2075099242 startingPage "4327" @default.
• W2075099242 abstract "Neuroplastin-65 and -55 (previously known as gp65 and gp55) are glycoproteins of the Ig superfamily that are enriched in rat forebrain synaptic membrane preparations. Whereas the two-Ig domain isoform neuroplastin-55 is expressed in many tissues, the three-Ig domain isoform neuroplastin-65 is brain-specific and enriched in postsynaptic density (PSD) protein preparations. Here, we have assessed the function of neuroplastin in long-term synaptic plasticity. Immunocytochemical studies with neuroplastin-65-specific antibodies differentially stain distinct synaptic neuropil regions of the rat hippocampus with most prominent immunoreactivity in the CA1 region and the proximal molecular layer of the dentate gyrus. Kainate-induced seizures cause a significant enhancement of neuroplastin-65 association with PSDs. Similarly, long-term potentiation (LTP) of CA1 synapses in hippocampal slices enhanced the association of neuroplastin-65 with a detergent-insoluble PSD-enriched protein fraction. Several antibodies against the neuroplastins, including one specific for neuroplastin-65, inhibited the maintenance of LTP. A similar effect was observed when recombinant fusion protein containing the three extracellular Ig domains of neuroplastin-65 was applied to hippocampal slices before LTP induction. Microsphere binding experiments using neuroplastin-F(c) chimeric proteins show that constructs containing Ig1-3 or Ig1 domains, but not Ig2-3 domains mediate homophilic adhesion. These data suggest that neuroplastin plays an essential role in implementing long-term changes in synaptic activity, possibly by means of a homophilic adhesion mechanism." @default.
• W2075099242 created "2016-06-24" @default.
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• W2075099242 date "2000-04-04" @default.
• W2075099242 modified "2023-09-29" @default.
• W2075099242 title "The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses" @default.
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• W2075099242 doi "https://doi.org/10.1073/pnas.080389297" @default.
• W2075099242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/18241" @default.
• W2075099242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10759566" @default.
• W2075099242 hasPublicationYear "2000" @default.
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